"Saquinavir" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases, and also inhibits CYTOCHROME P-450 CYP3A.
| Descriptor ID |
D019258
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| MeSH Number(s) |
D03.633.100.531.770 D03.633.100.810.900
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Saquinavir".
Below are MeSH descriptors whose meaning is more specific than "Saquinavir".
This graph shows the total number of publications written about "Saquinavir" by people in this website by year, and whether "Saquinavir" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 2 | 1 | 3 |
| 2012 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Saquinavir" by people in Profiles.
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Current evidence for the risk of PR prolongation, QRS widening, QT prolongation, from lopinavir, ritonavir, atazanavir, and saquinavir: A systematic review. Medicine (Baltimore). 2021 Aug 06; 100(31):e26787.
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Computational drug repurposing study of antiviral drugs against main protease, RNA polymerase, and spike proteins of SARS-CoV-2 using molecular docking method. J Basic Clin Physiol Pharmacol. 2021 Jul 15; 33(1):85-95.
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Molecular Docking and Virtual Screening Based Prediction of Drugs for COVID-19. Comb Chem High Throughput Screen. 2021; 24(5):716-728.
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Identification of saquinavir as a potent inhibitor of dimeric SARS-CoV2 main protease through MM/GBSA. J Mol Model. 2020 Nov 12; 26(12):340.
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Drug binding dynamics of the dimeric SARS-CoV-2 main protease, determined by molecular dynamics simulation. Sci Rep. 2020 10 12; 10(1):16986.
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Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19). Pathog Dis. 2020 06 01; 78(4).
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A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med Infect Dis. 2020 May - Jun; 35:101646.
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Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury. Mol Med. 2017 06; 23:92-100.
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Saquinavir inhibits early events associated with establishment of HIV-1 infection: potential role for protease inhibitors in prevention. Antimicrob Agents Chemother. 2012 Aug; 56(8):4381-90.
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Once-daily dosing of saquinavir soft-gel capsules and ritonavir combination in HIV-1-infected patients (IMEA015 study). Antivir Ther. 2004 Apr; 9(2):247-56.