Protein Tyrosine Phosphatase, Non-Receptor Type 22
"Protein Tyrosine Phosphatase, Non-Receptor Type 22" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
| Descriptor ID |
D054596
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| MeSH Number(s) |
D08.811.277.352.650.775.300.930 D12.644.360.585.930 D12.776.476.564.930
|
| Concept/Terms |
Protein Tyrosine Phosphatase, Non-Receptor Type 22- Protein Tyrosine Phosphatase, Non-Receptor Type 22
- Protein Tyrosine Phosphatase, Non Receptor Type 22
- PTPase Lyp
- Lymphoid Phosphatase
- Tyrosine Protein Phosphatase, Non-Receptor Type 22
- Tyrosine Protein Phosphatase, Non Receptor Type 22
- PTPN-22 Protein
- PTPN 22 Protein
- Protein-Tyrosine Phosphatase Lyp
- Protein Tyrosine Phosphatase Lyp
|
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 22".
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 22".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 22" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 22" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 3 | 0 | 3 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 22" by people in Profiles.
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Utilizing a PTPN22 gene signature to predict response to targeted therapies in rheumatoid arthritis. J Autoimmun. 2019 07; 101:121-130.
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Single Nucleotide Polymorphisms of PTPN22 Gene in Iranian Patients with Ulcerative Colitis. Fetal Pediatr Pathol. 2019 Feb; 38(1):8-13.
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Association of PTPN22 Single Nucleotide Polymorphisms with Celiac Disease. Fetal Pediatr Pathol. 2017 Jun; 36(3):195-202.
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Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis. Arthritis Rheumatol. 2017 05; 69(5):1054-1066.
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PTPN22 Single-Nucleotide Polymorphisms in Iranian Patients with Type 1 Diabetes Mellitus. Immunol Invest. 2017 May; 46(4):409-418.