Xiaotao Lu

InstitutionVanderbilt University Medical Center
AddressNashville
Tennessee
United States
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 4 Covid-19 publications, with a maximum of 1 publications in April 2020 and July 2020 and January 2021 and August 2021
    All Publications
    Bar chart showing 23 publications over 14 distinct years, with a maximum of 3 publications in 2004
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

    To see the data from both graphs as text, click here.
    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
    Sort By:     Newest   |   Oldest   |   Most Cited   |   Most Discussed
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pegu A, O'Connell SE, Schmidt SD, O'Dell S, Talana CA, Lai L, Albert J, Anderson E, Bennett H, Corbett KS, Flach B, Jackson L, Leav B, Ledgerwood JE, Luke CJ, Makowski M, Nason MC, Roberts PC, Roederer M, Rebolledo PA, Rostad CA, Rouphael NG, Shi W, Wang L, Widge AT, Yang ES, Beigel JH, Graham BS, Mascola JR, Suthar MS, McDermott AB, Doria-Rose NA, Arega J, Beigel JH, Buchanan W, Elsafy M, Hoang B, Lampley R, Kolhekar A, Koo H, Luke C, Makhene M, Nayak S, Pikaart-Tautges R, Roberts PC, Russell J, Sindall E, Albert J, Kunwar P, Makowski M, Anderson EJ, Bechnak A, Bower M, Camacho-Gonzalez AF, Collins M, Drobeniuc A, Edara VV, Edupuganti S, Floyd K, Gibson T, Ackerley CMG, Johnson B, Kamidani S, Kao C, Kelley C, Lai L, Macenczak H, McCullough MP, Peters E, Phadke VK, Rebolledo PA, Rostad CA, Rouphael N, Scherer E, Sherman A, Stephens K, Suthar MS, Teherani M, Traenkner J, et al. Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants. Science. 2021 09 17; 373(6561):1372-1377. PMID: 34385356.
      Citations: 34     Fields:    Translation:Humans
    2. Gribble J, Stevens LJ, Agostini ML, Anderson-Daniels J, Chappell JD, Lu X, Pruijssers AJ, Routh AL, Denison MR. The coronavirus proofreading exoribonuclease mediates extensive viral recombination. PLoS Pathog. 2021 01; 17(1):e1009226. PMID: 33465137.
      Citations: 34     Fields:    Translation:Humans
    3. Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, Graham RL, Perry JK, Du Pont V, Pitts J, Ma B, Babusis D, Murakami E, Feng JY, Bilello JP, Porter DP, Cihlar T, Baric RS, Denison MR, Sheahan TP. Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell Rep. 2020 07 21; 32(3):107940. PMID: 32668216.
      Citations: 149     Fields:    
    4. Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 04 29; 12(541). PMID: 32253226.
      Citations: 271     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    5. Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR. Small-Molecule Antiviral ß-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance. J Virol. 2019 12 15; 93(24). PMID: 31578288.
      Citations: 57     Fields:    Translation:AnimalsCells
    6. Graepel KW, Agostini ML, Lu X, Sexton NR, Denison MR. Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus. J Virol. 2019 10 15; 93(20). PMID: 31341046.
      Citations: 4     Fields:    Translation:Cells
    7. Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio. 2018 03 06; 9(2). PMID: 29511076.
      Citations: 521     Fields:    Translation:AnimalsCells
    8. Case JB, Li Y, Elliott R, Lu X, Graepel KW, Sexton NR, Smith EC, Weiss SR, Denison MR. Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity. J Virol. 2018 01 01; 92(1). PMID: 29046453.
      Citations: 27     Fields:    Translation:AnimalsCells
    9. Graepel KW, Lu X, Case JB, Sexton NR, Smith EC, Denison MR. Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations. mBio. 2017 11 07; 8(6). PMID: 29114026.
      Citations: 21     Fields:    Translation:AnimalsCells
    10. Freeman MC, Graham RL, Lu X, Peek CT, Denison MR. Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation. J Virol. 2014 May; 88(10):5319-27. PMID: 24623413.
      Citations: 13     Fields:    Translation:AnimalsCells
    11. Stobart CC, Sexton NR, Munjal H, Lu X, Molland KL, Tomar S, Mesecar AD, Denison MR. Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity. J Virol. 2013 Dec; 87(23):12611-8. PMID: 24027335.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    12. Beachboard DC, Lu X, Baker SC, Denison MR. Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive. Virology. 2013 Jan 20; 435(2):210-3. PMID: 23099203.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Stobart CC, Lee AS, Lu X, Denison MR. Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity. J Virol. 2012 May; 86(9):4801-10. PMID: 22345451.
      Citations: 18     Fields:    Translation:AnimalsCells
    14. Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR. Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. PLoS Pathog. 2010 May 06; 6(5):e1000896. PMID: 20463816.
      Citations: 184     Fields:    Translation:AnimalsCells
    15. Sparks JS, Donaldson EF, Lu X, Baric RS, Denison MR. A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing. J Virol. 2008 Jun; 82(12):5999-6008. PMID: 18385240.
      Citations: 10     Fields:    Translation:AnimalsCells
    16. Sparks JS, Lu X, Denison MR. Genetic analysis of Murine hepatitis virus nsp4 in virus replication. J Virol. 2007 Nov; 81(22):12554-63. PMID: 17855548.
      Citations: 22     Fields:    Translation:AnimalsCells
    17. Eckerle LD, Lu X, Sperry SM, Choi L, Denison MR. High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. J Virol. 2007 Nov; 81(22):12135-44. PMID: 17804504.
      Citations: 142     Fields:    Translation:AnimalsCells
    18. Eckerle LD, Brockway SM, Sperry SM, Lu X, Denison MR. Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture. Adv Exp Med Biol. 2006; 581:55-60. PMID: 17037504.
      Citations: 9     Fields:    Translation:AnimalsCells
    19. Brockway SM, Lu XT, Peters TR, Dermody TS, Denison MR. Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. J Virol. 2004 Nov; 78(21):11551-62. PMID: 15479796.
      Citations: 31     Fields:    Translation:AnimalsCells
    20. Prentice E, McAuliffe J, Lu X, Subbarao K, Denison MR. Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins. J Virol. 2004 Sep; 78(18):9977-86. PMID: 15331731.
      Citations: 146     Fields:    Translation:AnimalsCells
    21. Denison MR, Yount B, Brockway SM, Graham RL, Sims AC, Lu X, Baric RS. Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication. J Virol. 2004 Jun; 78(11):5957-65. PMID: 15140993.
      Citations: 31     Fields:    Translation:Cells
    22. Brockway SM, Clay CT, Lu XT, Denison MR. Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase. J Virol. 2003 Oct; 77(19):10515-27. PMID: 12970436.
      Citations: 64     Fields:    Translation:AnimalsCells