Andrew D Mesecar

InstitutionPurdue University
AddressWest Lafayette
Indiana
United States
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 6 Covid-19 publications, with a maximum of 2 publications in May 2020
    All Publications
    Bar chart showing 119 publications over 20 distinct years, with a maximum of 12 publications in 2008
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Citations: 2     Fields:    Translation:Humans
    2. Minasov G, Rosas-Lemus M, Shuvalova L, Inniss NL, Brunzelle JS, Daczkowski CM, Hoover P, Mesecar AD, Satchell KJF. Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O-methyl transfer by SARS-CoV-2 nsp16. Sci Signal. 2021 06 29; 14(689). PMID: 34131072.
      Citations: 2     Fields:    Translation:HumansCells
    3. Hattori SI, Higashi-Kuwata N, Hayashi H, Allu SR, Raghavaiah J, Bulut H, Das D, Anson BJ, Lendy EK, Takamatsu Y, Takamune N, Kishimoto N, Murayama K, Hasegawa K, Li M, Davis DA, Kodama EN, Yarchoan R, Wlodawer A, Misumi S, Mesecar AD, Ghosh AK, Mitsuya H. A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nat Commun. 2021 01 28; 12(1):668. PMID: 33510133.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    4. Citations: 219     Fields:    Translation:HumansCellsPHPublic Health
    5. Deng X, Chen Y, Mielech AM, Hackbart M, Kesely KR, Mettelman RC, O'Brien A, Chapman ME, Mesecar AD, Baker SC. Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus. J Virol. 2020 05 18; 94(11). PMID: 32188728.
      Citations: 10     Fields:    Translation:AnimalsCells
    6. Ghosh AK, Brindisi M, Shahabi D, Chapman ME, Mesecar AD. Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics. ChemMedChem. 2020 06 04; 15(11):907-932. PMID: 32324951.
      Citations: 62     Fields:    Translation:HumansPHPublic Health
    7. Clasman JR, Everett RK, Srinivasan K, Mesecar AD. Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease. Antiviral Res. 2020 02; 174:104661. PMID: 31765674.
      Citations: 13     Fields:    Translation:HumansCells
    8. Abuhammad A, Al-Aqtash RA, Anson BJ, Mesecar AD, Taha MO. Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus. J Mol Recognit. 2017 11; 30(11). PMID: 28608547.
      Citations: 8     Fields:    Translation:AnimalsCells
    9. Daczkowski CM, Dzimianski JV, Clasman JR, Goodwin O, Mesecar AD, Pegan SD. Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species. J Mol Biol. 2017 06 02; 429(11):1661-1683. PMID: 28438633.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    10. Clasman JR, Báez-Santos YM, Mettelman RC, O'Brien A, Baker SC, Mesecar AD. X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design. Sci Rep. 2017 01 12; 7:40292. PMID: 28079137.
      Citations: 20     Fields:    Translation:HumansCells
    11. St John SE, Anson BJ, Mesecar AD. X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus. Sci Rep. 2016 05 13; 6:25961. PMID: 27173881.
      Citations: 7     Fields:    Translation:AnimalsCells
    12. St John SE, Therkelsen MD, Nyalapatla PR, Osswald HL, Ghosh AK, Mesecar AD. X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5072-7. PMID: 26592814.
      Citations: 10     Fields:    Translation:Cells
    13. Chen Y, Savinov SN, Mielech AM, Cao T, Baker SC, Mesecar AD. X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions. J Biol Chem. 2015 Oct 16; 290(42):25293-306. PMID: 26296883.
      Citations: 17     Fields:    Translation:Cells
    14. St John SE, Tomar S, Stauffer SR, Mesecar AD. Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). Bioorg Med Chem. 2015 Sep 01; 23(17):6036-48. PMID: 26190463.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    15. Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD. Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS. J Biol Chem. 2015 Aug 07; 290(32):19403-22. PMID: 26055715.
      Citations: 48     Fields:    Translation:Cells
    16. Mielech AM, Deng X, Chen Y, Kindler E, Wheeler DL, Mesecar AD, Thiel V, Perlman S, Baker SC. Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis. J Virol. 2015 May; 89(9):4907-17. PMID: 25694594.
      Citations: 26     Fields:    Translation:AnimalsCells
    17. Báez-Santos YM, St John SE, Mesecar AD. The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds. Antiviral Res. 2015 Mar; 115:21-38. PMID: 25554382.
      Citations: 251     Fields:    Translation:HumansCells
    18. Báez-Santos YM, Mielech AM, Deng X, Baker S, Mesecar AD. Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus. J Virol. 2014 Nov; 88(21):12511-27. PMID: 25142582.
      Citations: 53     Fields:    Translation:HumansCells
    19. Deng X, StJohn SE, Osswald HL, O'Brien A, Banach BS, Sleeman K, Ghosh AK, Mesecar AD, Baker SC. Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance. J Virol. 2014 Oct; 88(20):11886-98. PMID: 25100843.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    20. Deng X, Agnihothram S, Mielech AM, Nichols DB, Wilson MW, StJohn SE, Larsen SD, Mesecar AD, Lenschow DJ, Baric RS, Baker SC. A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses. J Virol. 2014 Oct; 88(20):11825-33. PMID: 25100850.
      Citations: 12     Fields:    Translation:AnimalsCells
    21. Ratia K, Kilianski A, Baez-Santos YM, Baker SC, Mesecar A. Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease. PLoS Pathog. 2014 May; 10(5):e1004113. PMID: 24854014.
      Citations: 86     Fields:    Translation:HumansCells
    22. Agnihothram S, Yount BL, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. mBio. 2014 Mar 25; 5(2):e00047-14. PMID: 24667706.
      Citations: 34     Fields:    Translation:AnimalsCells
    23. Báez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD. X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. J Med Chem. 2014 Mar 27; 57(6):2393-412. PMID: 24568342.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    24. Mielech AM, Chen Y, Mesecar AD, Baker SC. Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities. Virus Res. 2014 Dec 19; 194:184-90. PMID: 24512893.
      Citations: 73     Fields:    Translation:Cells
    25. Mielech AM, Kilianski A, Baez-Santos YM, Mesecar AD, Baker SC. MERS-CoV papain-like protease has deISGylating and deubiquitinating activities. Virology. 2014 Feb; 450-451:64-70. PMID: 24503068.
      Citations: 109     Fields:    Translation:HumansCells
    26. Stobart CC, Sexton NR, Munjal H, Lu X, Molland KL, Tomar S, Mesecar AD, Denison MR. Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity. J Virol. 2013 Dec; 87(23):12611-8. PMID: 24027335.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    27. Turlington M, Chun A, Tomar S, Eggler A, Grum-Tokars V, Jacobs J, Daniels JS, Dawson E, Saldanha A, Chase P, Baez-Santos YM, Lindsley CW, Hodder P, Mesecar AD, Stauffer SR. Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorg Med Chem Lett. 2013 Nov 15; 23(22):6172-7. PMID: 24080461.
      Citations: 39     Fields:    Translation:HumansCells
    28. Jacobs J, Grum-Tokars V, Zhou Y, Turlington M, Saldanha SA, Chase P, Eggler A, Dawson ES, Baez-Santos YM, Tomar S, Mielech AM, Baker SC, Lindsley CW, Hodder P, Mesecar A, Stauffer SR. Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease. J Med Chem. 2013 Jan 24; 56(2):534-46. PMID: 23231439.
      Citations: 68     Fields:    Translation:Cells
    29. Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. J Med Chem. 2010 Jul 08; 53(13):4968-79. PMID: 20527968.
      Citations: 56     Fields:    Translation:AnimalsCells
    30. Clementz MA, Chen Z, Banach BS, Wang Y, Sun L, Ratia K, Baez-Santos YM, Wang J, Takayama J, Ghosh AK, Li K, Mesecar AD, Baker SC. Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases. J Virol. 2010 May; 84(9):4619-29. PMID: 20181693.
      Citations: 165     Fields:    Translation:HumansCells
    31. Ghosh AK, Takayama J, Aubin Y, Ratia K, Chaudhuri R, Baez Y, Sleeman K, Coughlin M, Nichols DB, Mulhearn DC, Prabhakar BS, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. J Med Chem. 2009 Aug 27; 52(16):5228-40. PMID: 19645480.
      Citations: 44     Fields:    Translation:AnimalsCells
    32. Frieman M, Ratia K, Johnston RE, Mesecar AD, Baric RS. Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling. J Virol. 2009 Jul; 83(13):6689-705. PMID: 19369340.
      Citations: 176     Fields:    Translation:HumansCells
    33. Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16119-24. PMID: 18852458.
      Citations: 179     Fields:    Translation:Cells
    34. Ghosh AK, Gong G, Grum-Tokars V, Mulhearn DC, Baker SC, Coughlin M, Prabhakar BS, Sleeman K, Johnson ME, Mesecar AD. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15; 18(20):5684-8. PMID: 18796354.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    35. Ghosh AK, Xi K, Grum-Tokars V, Xu X, Ratia K, Fu W, Houser KV, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2007 Nov 01; 17(21):5876-80. PMID: 17855091.
      Citations: 44     Fields:    Translation:Cells
    36. Grum-Tokars V, Ratia K, Begaye A, Baker SC, Mesecar AD. Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery. Virus Res. 2008 Apr; 133(1):63-73. PMID: 17397958.
      Citations: 67     Fields:    Translation:HumansCells
    37. Chen Z, Wang Y, Ratia K, Mesecar AD, Wilkinson KD, Baker SC. Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. J Virol. 2007 Jun; 81(11):6007-18. PMID: 17392370.
      Citations: 52     Fields:    Translation:HumansCells
    38. Ghosh AK, Xi K, Johnson ME, Baker SC, Mesecar AD. Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy. Annu Rep Med Chem. 2007 Feb 01; 41:183-196. PMID: 19649165.
      Citations: 17     
    39. Ratia K, Saikatendu KS, Santarsiero BD, Barretto N, Baker SC, Stevens RC, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5717-22. PMID: 16581910.
      Citations: 191     Fields:    Translation:Cells
    40. Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. Deubiquitinating activity of the SARS-CoV papain-like protease. Adv Exp Med Biol. 2006; 581:37-41. PMID: 17037501.
      Citations: 19     Fields:    Translation:HumansCells
    41. Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J Virol. 2005 Dec; 79(24):15189-98. PMID: 16306590.
      Citations: 244     Fields:    Translation:HumansCells
    42. Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD. Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. J Med Chem. 2005 Nov 03; 48(22):6767-71. PMID: 16250632.
      Citations: 55     Fields:    Translation:HumansAnimalsCells