Zinc Finger E-box Binding Homeobox 2
"Zinc Finger E-box Binding Homeobox 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that consists of 8 CYS2-HIS2 ZINC FINGERS flanking a central HOMEOBOX. It binds to the 5'-CACCT-3' DNA sequence located within E-BOX ELEMENTS of many genes essential for embryonic growth and development and regulates their activity; it represses transcription of the E-CADHERIN gene. Mutations in the ZEB2 gene are associated with MOWAT-WILSON SYNDROME.
| Descriptor ID |
D000074165
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| MeSH Number(s) |
D12.776.260.400.883 D12.776.260.703.700 D12.776.930.780.918
|
| Concept/Terms |
Zinc Finger E-box Binding Homeobox 2- Zinc Finger E-box Binding Homeobox 2
- Zinc Finger E box Binding Homeobox 2
- Zinc Finger E-box Binding Homeobox 2 Protein
- Zinc Finger E box Binding Homeobox 2 Protein
- Zeb2 Transcription Factor
- Transcription Factor, Zeb2
- Smad-Interacting Protein 1
- Smad Interacting Protein 1
|
Below are MeSH descriptors whose meaning is more general than "Zinc Finger E-box Binding Homeobox 2".
Below are MeSH descriptors whose meaning is more specific than "Zinc Finger E-box Binding Homeobox 2".
This graph shows the total number of publications written about "Zinc Finger E-box Binding Homeobox 2" by people in this website by year, and whether "Zinc Finger E-box Binding Homeobox 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 2 | 2 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zinc Finger E-box Binding Homeobox 2" by people in Profiles.
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The Alcohol Extract of Coreopsis tinctoria Nutt Ameliorates Diabetes and Diabetic Nephropathy in db/db Mice through miR-192/miR-200b and PTEN/AKT and ZEB2/ECM Pathways. Biomed Res Int. 2019; 2019:5280514.
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Phenotype and genotype of 87 patients with Mowat-Wilson syndrome and recommendations for care. Genet Med. 2018 09; 20(9):965-975.
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miR-200c inhibits TGF-ß-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer. Cancer Gene Ther. 2018 05; 25(3-4):68-76.
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Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma. Oncol Rep. 2018 Jan; 39(1):91-100.
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The lincRNA-ROR/miR-145 axis promotes invasion and metastasis in hepatocellular carcinoma via induction of epithelial-mesenchymal transition by targeting ZEB2. Sci Rep. 2017 07 05; 7(1):4637.
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Role and prognostic significance of the epithelial-mesenchymal transition factor ZEB2 in ovarian cancer. Oncotarget. 2015 Aug 07; 6(22):18966-79.
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Changes in microRNA expression during disease progression in patients with chronic viral hepatitis. Liver Int. 2015 Apr; 35(4):1324-33.