"Zinc Finger Protein Gli3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
| Descriptor ID |
D000074290
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| MeSH Number(s) |
D12.776.260.522.875 D12.776.260.703.900 D12.776.930.375.875 D12.776.930.780.972
|
| Concept/Terms |
Zinc Finger Protein Gli3- Zinc Finger Protein Gli3
- Glioma-Associated Oncogene Family Zinc Finger 3 Protein
- Glioma Associated Oncogene Family Zinc Finger 3 Protein
- GLI-Kruppel Family Member 3 Protein
- GLI Kruppel Family Member 3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Zinc Finger Protein Gli3".
Below are MeSH descriptors whose meaning is more specific than "Zinc Finger Protein Gli3".
This graph shows the total number of publications written about "Zinc Finger Protein Gli3" by people in this website by year, and whether "Zinc Finger Protein Gli3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zinc Finger Protein Gli3" by people in Profiles.
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Impact of Fundamental Diseases on Patients With COVID-19. Disaster Med Public Health Prep. 2020 Dec; 14(6):776-781.
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Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017 09 22; 292(38):15814-15825.
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Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin. PLoS One. 2015; 10(5):e0128006.