"Reverse Genetics" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The use of techniques that produce a functional MUTATION or an effect on GENE EXPRESSION of a specific gene of interest in order to identify the role or activity of the gene product of that gene.
| Descriptor ID |
D059386
|
| MeSH Number(s) |
E05.393.731
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Reverse Genetics".
Below are MeSH descriptors whose meaning is more specific than "Reverse Genetics".
This graph shows the total number of publications written about "Reverse Genetics" by people in this website by year, and whether "Reverse Genetics" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 1 | 3 |
| 2017 | 9 | 9 | 18 |
| 2018 | 5 | 3 | 8 |
| 2019 | 2 | 2 | 4 |
| 2020 | 3 | 1 | 4 |
| 2021 | 3 | 1 | 4 |
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Below are the most recent publications written about "Reverse Genetics" by people in Profiles.
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A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses. Nat Commun. 2021 06 08; 12(1):3431.
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Applications of Deep Mutational Scanning in Virology. Viruses. 2021 05 28; 13(6).
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Infectious Clones Produce SARS-CoV-2 That Causes Severe Pulmonary Disease in Infected K18-Human ACE2 Mice. mBio. 2021 04 20; 12(2).
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Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction. Cell Rep. 2021 04 20; 35(3):109014.
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A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biol. 2021 02; 19(2):e3001091.
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Engineering SARS-CoV-2 using a reverse genetic system. Nat Protoc. 2021 03; 16(3):1761-1784.
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Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response. Cell Host Microbe. 2021 03 10; 29(3):489-502.e8.
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The RNA Architecture of the SARS-CoV-2 3'-Untranslated Region. Viruses. 2020 12 21; 12(12).
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Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome. mBio. 2020 09 25; 11(5).
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Vaccine Development Against COVID-19 Prior to Pandemic Outbreaks, Using in vitro Evolution and Reverse Genetics. Front Immunol. 2020; 11:2051.