"Smad4 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
| Descriptor ID |
D051901
|
| MeSH Number(s) |
D12.644.360.024.334.750 D12.776.157.057.170.750 D12.776.260.713.750 D12.776.476.024.428.750 D12.776.624.776.760 D12.776.930.806.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Smad4 Protein".
Below are MeSH descriptors whose meaning is more specific than "Smad4 Protein".
This graph shows the total number of publications written about "Smad4 Protein" by people in this website by year, and whether "Smad4 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 2 | 3 | 5 |
| 2019 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Smad4 Protein" by people in Profiles.
-
Identification of Transcription Factors Regulating SARS-CoV-2 Entry Genes in the Intestine. Cell Mol Gastroenterol Hepatol. 2021; 11(1):181-184.
-
ALK phosphorylates SMAD4 on tyrosine to disable TGF-ß tumour suppressor functions. Nat Cell Biol. 2019 02; 21(2):179-189.
-
Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals. Mol Cancer. 2018 11 12; 17(1):157.
-
Trim33 mediates the proinflammatory function of Th17 cells. J Exp Med. 2018 07 02; 215(7):1853-1868.
-
ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis. Cancer Res. 2018 04 15; 78(8):1972-1985.
-
TGF-ß1 Promotes Hepatocellular Carcinoma Invasion and Metastasis via ERK Pathway-Mediated FGFR4 Expression. Cell Physiol Biochem. 2018; 45(4):1690-1699.
-
Smad4 Loss Correlates With Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation. Pancreas. 2018 02; 47(2):208-212.
-
Smad4 deletion in blood vessel endothelial cells promotes ovarian cancer metastasis. Int J Oncol. 2017 May; 50(5):1693-1700.
-
Team work and cytopathology molecular diagnosis of solid pancreatic lesions. Dig Endosc. 2017 Sep; 29(6):657-666.
-
Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFß1. Cell Commun Signal. 2014 Mar 26; 12:20.