Pregnancy-Associated Plasma Protein-A
"Pregnancy-Associated Plasma Protein-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.
| Descriptor ID |
D011266
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| MeSH Number(s) |
D08.811.277.656.300.480.632 D08.811.277.656.675.374.632 D12.776.780.700
|
| Concept/Terms |
Pregnancy-Associated Plasma Protein-A- Pregnancy-Associated Plasma Protein-A
- Pregnancy Associated Plasma Protein A
- IGFBP-4 Protease
- IGFBP 4 Protease
- Protease, IGFBP-4
- IGFBP-4-Specific Proteinase
- Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease
- Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease
- PAPP-A
- PAPP-alpha
- PAPP alpha
- Pregnancy Associated alpha Plasma Protein
- Pregnancy-Associated alpha-Plasma Protein
- IGFBP-4 Metalloproteinase
- IGFBP 4 Metalloproteinase
- Metalloproteinase, IGFBP-4
- Insulin-Like-Growth Factor Binding Protein-4 Protease
- Insulin Like Growth Factor Binding Protein 4 Protease
|
Below are MeSH descriptors whose meaning is more general than "Pregnancy-Associated Plasma Protein-A".
Below are MeSH descriptors whose meaning is more specific than "Pregnancy-Associated Plasma Protein-A".
This graph shows the total number of publications written about "Pregnancy-Associated Plasma Protein-A" by people in this website by year, and whether "Pregnancy-Associated Plasma Protein-A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2017 | 2 | 1 | 3 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Pregnancy-Associated Plasma Protein-A" by people in Profiles.
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Microarray analysis: First-trimester maternal serum free ß-hCG and the risk of significant copy number variants. Prenat Diagn. 2018 11; 38(12):971-978.
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Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR. Mol Med Rep. 2018 05; 17(5):6435-6440.
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Aspirin for Evidence-Based Preeclampsia Prevention trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia. Am J Obstet Gynecol. 2017 12; 217(6):685.e1-685.e5.
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Pregnancy-associated plasma protein-A (PAPP-A) and the proform of the eosinophil major basic protein (ProMBP) are associated with increased risk of death in heart failure patients. Scand J Clin Lab Invest. 2017 Sep; 77(5):352-357.
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First-Trimester and Second-Trimester Maternal Serum Biomarkers as Predictors of Placental Abruption. Obstet Gynecol. 2017 03; 129(3):465-472.
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Ischemia-modified albumin in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2013 Oct; 170(2):348-51.