"Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.
| Descriptor ID |
D028884
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| MeSH Number(s) |
D12.776.157.530.750.500 D12.776.543.585.750.500 D12.776.660.502
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Karyopherins".
Below are MeSH descriptors whose meaning is more specific than "Karyopherins".
This graph shows the total number of publications written about "Karyopherins" by people in this website by year, and whether "Karyopherins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2017 | 3 | 0 | 3 |
| 2018 | 2 | 2 | 4 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Karyopherins" by people in Profiles.
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Karyopherin abnormalities in neurodegenerative proteinopathies. Brain. 2021 11 29; 144(10):2915-2932.
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Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo. Antiviral Res. 2021 08; 192:105115.
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Predicting cryptic ligand binding sites based on normal modes guided conformational sampling. Proteins. 2021 04; 89(4):416-426.
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Exportin 1 inhibition as antiviral therapy. Drug Discov Today. 2020 10; 25(10):1775-1781.
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Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma. N Engl J Med. 2019 08 22; 381(8):727-738.
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Phosphorylation and dephosphorylation of threonine 188 in nucleoprotein is crucial for the replication of influenza A virus. Virology. 2018 07; 520:30-38.
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Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting. Biochim Biophys Acta Mol Cell Res. 2018 08; 1865(8):1114-1129.
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Teriflunomide promotes oligodendroglial differentiation and myelination. J Neuroinflammation. 2018 Mar 13; 15(1):76.
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Importin-ß and exportin-5 are indicators of acute viral infection: Correlation of their detection with commercially available detection kits. Ann Diagn Pathol. 2018 Jun; 34:36-41.
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Respiratory Syncytial Virus Nonstructural Protein 1 Blocks Glucocorticoid Receptor Nuclear Translocation by Targeting IPO13 and May Account for Glucocorticoid Insensitivity. J Infect Dis. 2017 12 27; 217(1):35-46.