"Cathepsin D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
| Descriptor ID |
D002402
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| MeSH Number(s) |
D08.811.277.656.074.500.180 D08.811.277.656.224.187 D08.811.277.656.300.048.180
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin D".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin D".
This graph shows the total number of publications written about "Cathepsin D" by people in this website by year, and whether "Cathepsin D" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cathepsin D" by people in Profiles.
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Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome. Cardiovasc Hematol Disord Drug Targets. 2020; 20(2):116-121.
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Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis. Autophagy. 2020 05; 16(5):811-825.
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Evaluation of serum cathepsin D concentrations in coronary artery disease. Indian Heart J. 2018 Jul - Aug; 70(4):471-475.
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Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes. Dis Markers. 2017; 2017:5286408.
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Cerebrospinal fluid ß-glucocerebrosidase activity is reduced in parkinson's disease patients. Mov Disord. 2017 Oct; 32(10):1423-1431.
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Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: a proof-of-concept pilot study. Circulation. 2010 Apr 06; 121(13):1465-73.
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The innate immunity role of cathepsin-D is linked to Trp-491 and Trp-492 residues of listeriolysin O. Mol Microbiol. 2009 May; 72(3):668-82.
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Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC class II-positive vesicles in immature dendritic cells. J Immunol. 1997 Oct 15; 159(8):3707-16.
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A highly efficient, cell-free translation/translocation system prepared from Xenopus eggs. Nucleic Acids Res. 1991 Dec 11; 19(23):6405-12.