"Cathepsin L" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY GRANULES.
| Descriptor ID |
D056668
|
| MeSH Number(s) |
D08.811.277.656.224.407 D08.811.277.656.262.500.157 D08.811.277.656.300.200.157
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin L".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin L".
This graph shows the total number of publications written about "Cathepsin L" by people in this website by year, and whether "Cathepsin L" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 3 | 3 |
| 2008 | 0 | 3 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 4 | 0 | 4 |
| 2017 | 1 | 3 | 4 |
| 2018 | 1 | 2 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 2 | 3 |
| 2021 | 2 | 6 | 8 |
To return to the timeline, click here.
Below are the most recent publications written about "Cathepsin L" by people in Profiles.
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Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L. PLoS One. 2021; 16(8):e0256141.
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MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L. ChemMedChem. 2022 01 05; 17(1):e202100456.
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Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases. J Med Chem. 2021 08 12; 64(15):11267-11287.
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TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells. EMBO J. 2021 08 16; 40(16):e107821.
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ILRUN Downregulates ACE2 Expression and Blocks Infection of Human Cells by SARS-CoV-2. J Virol. 2021 07 12; 95(15):e0032721.
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SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19. Int J Mol Sci. 2021 Apr 25; 22(9).
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A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells. ACS Chem Biol. 2021 04 16; 16(4):642-650.
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Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 03 27; 6(1):134.
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ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model. Biochem Biophys Res Commun. 2021 05 28; 555:134-139.
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Polyunsaturated ?-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry. Sci Rep. 2021 03 04; 11(1):5207.