"Cathepsin B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
Descriptor ID |
D002401
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MeSH Number(s) |
D08.811.277.656.224.125 D08.811.277.656.262.500.133 D08.811.277.656.300.200.133
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cathepsin B".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin B".
This graph shows the total number of publications written about "Cathepsin B" by people in this website by year, and whether "Cathepsin B" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2006 | 1 | 0 | 1 |
2008 | 1 | 0 | 1 |
2012 | 1 | 0 | 1 |
2013 | 0 | 1 | 1 |
2016 | 1 | 0 | 1 |
2017 | 0 | 2 | 2 |
2018 | 1 | 3 | 4 |
2019 | 0 | 1 | 1 |
2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Cathepsin B" by people in Profiles.
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Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L. PLoS One. 2021; 16(8):e0256141.
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Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage. Bioorg Chem. 2021 10; 115:105196.
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Simultaneous Inhibition of SARS-CoV-2 Entry Pathways by Cyclosporine. ACS Chem Neurosci. 2021 03 03; 12(5):930-944.
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Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes. Hereditas. 2021 Jan 04; 158(1):4.
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Female reproductive tract has low concentration of SARS-CoV2 receptors. PLoS One. 2020; 15(12):e0243959.
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Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection. PLoS Comput Biol. 2020 12; 16(12):e1008461.
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Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer. Aging (Albany NY). 2020 11 20; 12(22):22370-22389.
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Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes. J Mol Cell Cardiol. 2020 10; 147:88-91.
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Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production. Signal Transduct Target Ther. 2020 07 08; 5(1):121.
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Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment. Int J Antimicrob Agents. 2020 Jun; 55(6):106004.