"Calpain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Descriptor ID |
D002154
|
MeSH Number(s) |
D08.811.277.656.262.500.120 D08.811.277.656.300.200.120
|
Concept/Terms |
Calpain- Calpain
- Calcium-Activated Protease
- Calcium Activated Protease
- Protease, Calcium-Activated
- Calcium-Dependent Neutral Proteinase
- Calcium Dependent Neutral Proteinase
- Neutral Proteinase, Calcium-Dependent
- Proteinase, Calcium-Dependent Neutral
- Calcium-Dependent Neutral Protease
- Calcium Dependent Neutral Protease
- Neutral Protease, Calcium-Dependent
- Protease, Calcium-Dependent Neutral
- Desminase
- Ca2+-Activated Protease
- Ca2+ Activated Protease
- Protease, Ca2+-Activated
- Calcium-Activated Neutral Proteinase
- Calcium Activated Neutral Proteinase
- Neutral Proteinase, Calcium-Activated
- Proteinase, Calcium-Activated Neutral
- Calcium-Activated Neutral Protease
- Calcium Activated Neutral Protease
- Neutral Protease, Calcium-Activated
- Protease, Calcium-Activated Neutral
|
Below are MeSH descriptors whose meaning is more general than "Calpain".
Below are MeSH descriptors whose meaning is more specific than "Calpain".
This graph shows the total number of publications written about "Calpain" by people in this website by year, and whether "Calpain" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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2009 | 1 | 0 | 1 |
2012 | 1 | 0 | 1 |
2013 | 1 | 0 | 1 |
2017 | 3 | 3 | 6 |
2018 | 3 | 0 | 3 |
2019 | 1 | 1 | 2 |
2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Calpain" by people in Profiles.
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A new class of a-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities. Eur J Med Chem. 2021 Apr 05; 215:113267.
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Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):5061-5070.
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Amorphous nano-selenium quantum dots improve endothelial dysfunction in rats and prevent atherosclerosis in mice through Na+/H+ exchanger 1 inhibition. Vascul Pharmacol. 2019 04; 115:26-32.
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Ischemia-reperfusion induces death receptor-independent necroptosis via calpain-STAT3 activation in a lung transplant setting. Am J Physiol Lung Cell Mol Physiol. 2018 10 01; 315(4):L595-L608.
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Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB. PLoS Pathog. 2018 07; 14(7):e1007111.
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Calpain inhibition attenuates bleomycin-induced pulmonary fibrosis via switching the development of epithelial-mesenchymal transition. Naunyn Schmiedebergs Arch Pharmacol. 2018 07; 391(7):695-704.
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Photoreceptor Cell-Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage. Invest Ophthalmol Vis Sci. 2018 04 01; 59(5):1810-1821.
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Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain. Int J Biochem Cell Biol. 2018 02; 95:73-84.
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Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication. Open Biol. 2017 10; 7(10).
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Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease. EBioMedicine. 2017 Sep; 23:173-184.