"Papain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.
| Descriptor ID |
D010206
|
| MeSH Number(s) |
D08.811.277.656.262.500.585 D08.811.277.656.300.200.585
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Papain".
Below are MeSH descriptors whose meaning is more specific than "Papain".
This graph shows the total number of publications written about "Papain" by people in this website by year, and whether "Papain" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 1 | 3 |
| 1998 | 1 | 1 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2014 | 3 | 0 | 3 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 2 | 4 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Papain" by people in Profiles.
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Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors. Molecules. 2021 Aug 12; 26(16).
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Inhibition of Cysteine Proteases by 6,6'-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea. Molecules. 2021 Aug 05; 26(16).
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The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease. ACS Infect Dis. 2021 06 11; 7(6):1483-1502.
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Unraveling the unbinding pathways of SARS-CoV-2 Papain-like proteinase known inhibitors by Supervised Molecular Dynamics simulation. PLoS One. 2021; 16(5):e0251910.
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Meticulous assessment of natural compounds from NPASS database for identifying analogue of GRL0617, the only known inhibitor for SARS-CoV2 papain-like protease (PLpro) using rigorous computational workflow. Mol Divers. 2022 Feb; 26(1):389-407.
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Identifying structural-functional analogue of GRL0617, the only well-established inhibitor for papain-like protease (PLpro) of SARS-CoV2 from the pool of fungal metabolites using docking and molecular dynamics simulation. Mol Divers. 2022 Feb; 26(1):309-329.
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Exploring naphthyl derivatives as SARS-CoV papain-like protease (PLpro) inhibitors and its implications in COVID-19 drug discovery. Mol Divers. 2022 Feb; 26(1):215-228.
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Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors. Nat Commun. 2021 02 02; 12(1):743.
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Computational Evidences of Phytochemical Mediated Disruption of PLpro Driven Replication of SARS-CoV-2: A Therapeutic Approach against COVID-19. Curr Pharm Biotechnol. 2021; 22(10):1350-1359.
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Papain-like cysteine proteinase zone (PCP-zone) and PCP structural catalytic core (PCP-SCC) of enzymes with cysteine proteinase fold. Int J Biol Macromol. 2020 Dec 15; 165(Pt A):1438-1446.