"alpha 1-Antitrypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
| Descriptor ID |
D000515
|
| MeSH Number(s) |
D12.644.861.035 D12.776.124.050.070 D12.776.124.790.106.085 D12.776.377.715.085.085 D12.776.395.068 D12.776.872.035
|
| Concept/Terms |
alpha 1-Antitrypsin- alpha 1-Antitrypsin
- alpha 1 Antitrypsin
- alpha 1 Antiprotease
- Antiprotease, alpha 1
- Serpin A1
- alpha 1-Protease Inhibitor
- Inhibitor, alpha 1-Protease
- alpha 1 Protease Inhibitor
- alpha 1-Proteinase Inhibitor
- Inhibitor, alpha 1-Proteinase
- alpha 1 Proteinase Inhibitor
- Trypsin Inhibitor, alpha 1-Antitrypsin
- Trypsin Inhibitor, alpha 1 Antitrypsin
- A1PI
- alpha 1-Antiproteinase
- 1-Antiproteinase, alpha
- alpha 1 Antiproteinase
|
Below are MeSH descriptors whose meaning is more general than "alpha 1-Antitrypsin".
Below are MeSH descriptors whose meaning is more specific than "alpha 1-Antitrypsin".
This graph shows the total number of publications written about "alpha 1-Antitrypsin" by people in this website by year, and whether "alpha 1-Antitrypsin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 14 | 6 | 20 |
| 2018 | 11 | 3 | 14 |
| 2019 | 2 | 2 | 4 |
| 2020 | 2 | 1 | 3 |
| 2021 | 6 | 1 | 7 |
To return to the timeline, click here.
Below are the most recent publications written about "alpha 1-Antitrypsin" by people in Profiles.
-
Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by a-1 Antitrypsin. Int J Mol Sci. 2021 Jul 26; 22(15).
-
Therapeutic Application of Alpha-1 Antitrypsin in COVID-19. Am J Respir Crit Care Med. 2021 07 15; 204(2):224-227.
-
Insights into the potential role of alpha1-antitrypsin in COVID-19 patients: Mechanisms, current update, and future perspectives. Clin Respir J. 2021 Sep; 15(9):1019-1024.
-
COVID-19 vaccination in patients with a1-antitrypsin deficiency. Lancet Respir Med. 2021 08; 9(8):818-820.
-
SARS-CoV-2 infection in alpha1-antitrypsin deficiency. Respir Med. 2021 08; 184:106466.
-
a1-Antitrypsin: Key Player or Bystander in Acute Respiratory Distress Syndrome? Anesthesiology. 2021 05 01; 134(5):792-808.
-
Correlation of Low Levels of a-1 Antitrypsin and Elevation of Neutrophil to Lymphocyte Ratio with Higher Mortality in Severe COVID-19 Patients. Mediators Inflamm. 2021; 2021:5555619.
-
A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial. Trials. 2021 Apr 19; 22(1):288.
-
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection. Nat Commun. 2021 03 19; 12(1):1726.
-
Protease-antiprotease imbalance in patients with severe COVID-19. Clin Chem Lab Med. 2021 07 27; 59(8):e330-e334.