"Factor XII" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
| Descriptor ID |
D005174
|
| MeSH Number(s) |
D12.776.124.125.450 D23.119.450
|
| Concept/Terms |
Factor XII- Factor XII
- Factor Twelve
- Hageman Factor
- Factor 12
- Coagulation Factor XII
|
Below are MeSH descriptors whose meaning is more general than "Factor XII".
Below are MeSH descriptors whose meaning is more specific than "Factor XII".
This graph shows the total number of publications written about "Factor XII" by people in this website by year, and whether "Factor XII" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
| 2017 | 3 | 0 | 3 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Factor XII" by people in Profiles.
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Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation. EBioMedicine. 2021 May; 67:103382.
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Airborne Fine Particles Induce Hematological Effects through Regulating the Crosstalk of the Kallikrein-Kinin, Complement, and Coagulation Systems. Environ Sci Technol. 2019 03 05; 53(5):2840-2851.
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Differential contribution of tissue factor and Factor XII to thrombin generation triggered by breast and pancreatic cancer cells. Int J Oncol. 2017 Dec; 51(6):1747-1756.
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Coagulation factor XII regulates inflammatory responses in human lungs. Thromb Haemost. 2017 10 05; 117(10):1896-1907.
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FXII promotes proteolytic processing of the LRP1 ectodomain. Biochim Biophys Acta Gen Subj. 2017 Aug; 1861(8):2088-2098.
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The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis. Blood. 2015 Sep 10; 126(11):1379-89.