Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
|
| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
|
| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Actilyse- Actilyse
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
|
Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 2 | 3 |
| 2014 | 2 | 1 | 3 |
| 2015 | 3 | 0 | 3 |
| 2016 | 4 | 1 | 5 |
| 2017 | 46 | 27 | 73 |
| 2018 | 28 | 21 | 49 |
| 2019 | 8 | 7 | 15 |
| 2020 | 9 | 8 | 17 |
| 2021 | 8 | 6 | 14 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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Tissue Plasminogen Activator in Critically Ill Adults with COVID-19. Ann Am Thorac Soc. 2021 11; 18(11):1917-1921.
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Systemic thrombolysis in ischaemic stroke patients with COVID-19. Acta Neurol Scand. 2022 Jan; 145(1):47-52.
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National Trends in Telestroke Utilization in a US Commercial Platform Prior to the COVID-19 Pandemic. J Stroke Cerebrovasc Dis. 2021 Oct; 30(10):106035.
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COVID-19-associated ischaemic stroke due to underlying carotid artery thrombosis in a healthy young woman. BMJ Case Rep. 2021 Aug 03; 14(8).
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Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis. Microvasc Res. 2021 11; 138:104224.
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Increased resistance to fibrinolysis activation in patients with coronavirus disease 2019: a case series. Blood Coagul Fibrinolysis. 2021 Jun 01; 32(4):298-301.
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The characteristics and outcomes of critically Ill patients with COVID-19 who received systemic thrombolysis for presumed pulmonary embolism: an observational study. J Thromb Thrombolysis. 2021 Nov; 52(4):1061-1067.
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Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID-19: A single-center prospective longitudinal study. J Thromb Haemost. 2021 06; 19(6):1546-1557.
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Case of right ventricular and aortic thrombi in a patient with severe COVID-19. BMJ Case Rep. 2021 Apr 19; 14(4).
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Saddle pulmonary embolism in a pediatric patient with nephrotic syndrome and recent COVID-19 pneumonia: A case report. Am J Emerg Med. 2021 10; 48:376.e1-376.e2.