Proteasome Endopeptidase Complex
"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
| Descriptor ID |
D046988
|
| MeSH Number(s) |
D05.500.562.500 D08.811.277.656.918 D08.811.600.730
|
| Concept/Terms |
Proteasome Endopeptidase Complex- Proteasome Endopeptidase Complex
- Complex, Proteasome Endopeptidase
- Endopeptidase Complex, Proteasome
- Macropain
- Macroxyproteinase
- Multicatalytic Proteinase
- Proteinase, Multicatalytic
- Prosome
- Proteasome
- 20S Proteasome
- Proteasome, 20S
- Multicatalytic Endopeptidase Complex
- Complex, Multicatalytic Endopeptidase
- Endopeptidase Complex, Multicatalytic
|
Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".
Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".
This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2010 | 2 | 0 | 2 |
| 2012 | 0 | 2 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 7 | 14 | 21 |
| 2018 | 12 | 10 | 22 |
| 2019 | 2 | 3 | 5 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 3 | 3 |
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Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.
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Qing-Fei-Pai-Du decoction and wogonoside exert anti-inflammatory action through down-regulating USP14 to promote the degradation of activating transcription factor 2. FASEB J. 2021 09; 35(9):e21870.
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[Induced degradation of proteins by PROTACs and other strategies: towards promising drugs]. Biol Aujourdhui. 2021; 215(1-2):25-43.
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Proteomic Signature of Host Response to SARS-CoV-2 Infection in the Nasopharynx. Mol Cell Proteomics. 2021; 20:100134.
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Long-chain polyphosphates impair SARS-CoV-2 infection and replication. Sci Signal. 2021 07 06; 14(690).
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Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro. Signal Transduct Target Ther. 2021 06 01; 6(1):214.
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Protease Inhibition-An Established Strategy to Combat Infectious Diseases. Int J Mol Sci. 2021 May 28; 22(11).
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A new class of a-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities. Eur J Med Chem. 2021 Apr 05; 215:113267.
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Identification of CD8+ T cell epitopes through proteasome cleavage site predictions. BMC Bioinformatics. 2020 Dec 14; 21(Suppl 17):484.
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Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. Commun Biol. 2020 11 23; 3(1):715.
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Porcine deltacoronavirus nucleocapsid protein species-specifically suppressed IRF7-induced type I interferon production via ubiquitin-proteasomal degradation pathway. Vet Microbiol. 2020 Nov; 250:108853.