NFATC Transcription Factors
"NFATC Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
| Descriptor ID |
D050778
|
| MeSH Number(s) |
D12.776.930.608
|
| Concept/Terms |
NFATC Transcription Factors- NFATC Transcription Factors
- Transcription Factors, NFATC
- Transcription Factor NF-AT
- NF-AT, Transcription Factor
- Transcription Factor NF AT
- Nuclear Factor of Activated T-Cells, Cytoplasmic
- Nuclear Factor of Activated T Cells, Cytoplasmic
- NFAT Proteins
- NFATC Proteins
- Nuclear Factors of Activated T-Cells
- Nuclear Factors of Activated T Cells
- NF-AT Proteins
- NF AT Proteins
NFAT Transcription Factor 4- NFAT Transcription Factor 4
- NFATC3 Transcription Factor
- Factor, NFATC3 Transcription
- Transcription Factor, NFATC3
- NFATx Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein
- NF-AT4 Protein
- NF AT4 Protein
- NFAT4 Protein
- NFATC3 Protein
NFAT Transcription Factor 2- NFAT Transcription Factor 2
- NFAT-2 Protein
- NFAT 2 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein
- NFATC1 Protein
- NFATC1 Transcription Factor
- Factor, NFATC1 Transcription
- Transcription Factor, NFATC1
- NF-ATc1 Protein
- NF ATc1 Protein
- NFAT2 Protein
NFAT Transcription Factor 3- NFAT Transcription Factor 3
- NFATC4 Transcription Factor
- Transcription Factor, NFATC4
- NFAT3 Protein
- NFATC4 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein
- NF-AT3 Protein
- NF AT3 Protein
NFAT Transcription Factor 5- NFAT Transcription Factor 5
- Nuclear Factor of Activated T-Cells 5 Protein
- Nuclear Factor of Activated T Cells 5 Protein
- OREBP Protein
- Osmotic Response Element Binding Protein
- NFATL1 Protein
- Tonicity-Responsive Enhancer-Binding Protein
- Tonicity Responsive Enhancer Binding Protein
- NFAT5 Protein
- NFATz Protein
- TonEBP Protein
NFAT Transcription Factor 1- NFAT Transcription Factor 1
- NFATC2 Transcription Factor
- Factor, NFATC2 Transcription
- Transcription Factor, NFATC2
- NFAT1 Protein
- NFATC2 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein
- NFAT-1 Protein
- NFAT 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "NFATC Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "NFATC Transcription Factors".
This graph shows the total number of publications written about "NFATC Transcription Factors" by people in this website by year, and whether "NFATC Transcription Factors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2017 | 3 | 3 | 6 |
| 2018 | 1 | 2 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "NFATC Transcription Factors" by people in Profiles.
-
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3. Phytomedicine. 2020 Dec; 79:153350.
-
BDNF activates an NFI-dependent neurodevelopmental timing program by sequestering NFATc4. Mol Biol Cell. 2018 04 15; 29(8):975-987.
-
Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Transl Psychiatry. 2018 03 06; 8(1):55.
-
REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation. FASEB J. 2018 06; 32(6):3215-3228.
-
NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib. Int J Cancer. 2018 01 15; 142(2):322-333.
-
Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1-MDM2-p53 Pathway. Prog Mol Biol Transl Sci. 2017; 151:195-216.
-
Mechanisms of TFAM-mediated cardiomyocyte protection. Can J Physiol Pharmacol. 2018 Feb; 96(2):173-181.
-
Control of Pathological Cardiac Hypertrophy by Transcriptional Corepressor IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein 2). Hypertension. 2017 09; 70(3):515-523.
-
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy. Sci Rep. 2017 06 14; 7(1):3490.
-
Novel natural product therapeutics targeting both inflammation and cancer. Chin J Nat Med. 2017 Jun; 15(6):401-416.