Interferon Regulatory Factors
"Interferon Regulatory Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.
| Descriptor ID |
D050835
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| MeSH Number(s) |
D12.644.360.024.302 D12.776.157.057.050 D12.776.260.504 D12.776.476.024.385 D12.776.930.332
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Interferon Regulatory Factors".
Below are MeSH descriptors whose meaning is more specific than "Interferon Regulatory Factors".
This graph shows the total number of publications written about "Interferon Regulatory Factors" by people in this website by year, and whether "Interferon Regulatory Factors" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 8 | 9 | 17 |
| 2018 | 7 | 3 | 10 |
| 2019 | 2 | 4 | 6 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Interferon Regulatory Factors" by people in Profiles.
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HIF-1a is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes. Proc Natl Acad Sci U S A. 2021 06 29; 118(26).
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Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19. Front Immunol. 2021; 12:665773.
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Functional landscape of SARS-CoV-2 cellular restriction. Mol Cell. 2021 06 17; 81(12):2656-2668.e8.
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Involvement of Interleukin-1 Receptor-Associated Kinase 4 and Interferon Regulatory Factor 5 in the Immunopathogenesis of SARS-CoV-2 Infection: Implications for the Treatment of COVID-19. Front Immunol. 2021; 12:638446.
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Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease. J Immunol. 2021 04 15; 206(8):1691-1696.
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MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells. Cell Rep. 2021 01 12; 34(2):108628.
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The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells. Immunity. 2021 02 09; 54(2):235-246.e5.
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The type I interferon response in COVID-19: implications for treatment. Nat Rev Immunol. 2020 10; 20(10):585-586.
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Consensus transcriptional regulatory networks of coronavirus-infected human cells. Sci Data. 2020 09 22; 7(1):314.
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Working Hypothesis for Glucose Metabolism and SARS-CoV-2 Replication: Interplay Between the Hexosamine Pathway and Interferon RF5 Triggering Hyperinflammation. Role of BCG Vaccine? Front Endocrinol (Lausanne). 2020; 11:514.