STAT Transcription Factors
"STAT Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.
| Descriptor ID |
D050791
|
| MeSH Number(s) |
D12.644.360.024.342 D12.776.157.057.186 D12.776.476.024.430 D12.776.930.840
|
| Concept/Terms |
STAT Transcription Factors- STAT Transcription Factors
- Transcription Factors, STAT
- STAT (Signal Transducers and Activators of Transcription) Proteins
|
Below are MeSH descriptors whose meaning is more general than "STAT Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "STAT Transcription Factors".
This graph shows the total number of publications written about "STAT Transcription Factors" by people in this website by year, and whether "STAT Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 5 | 7 |
| 2018 | 4 | 1 | 5 |
| 2019 | 0 | 2 | 2 |
| 2020 | 0 | 5 | 5 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "STAT Transcription Factors" by people in Profiles.
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The Many Faces of JAKs and STATs Within the COVID-19 Storm. Front Immunol. 2021; 12:690477.
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SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation. EMBO J. 2021 08 02; 40(15):e107826.
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Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms. Int J Mol Sci. 2021 Jun 09; 22(12).
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Identification of human immune cell subtypes most responsive to IL-1ß-induced inflammatory signaling using mass cytometry. Sci Signal. 2021 03 09; 14(673).
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Network theoretic analysis of JAK/STAT pathway and extrapolation to drugs and viruses including COVID-19. Sci Rep. 2021 01 28; 11(1):2512.
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Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification. J Ethnopharmacol. 2021 May 10; 271:113854.
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Immunopathogenesis and treatment of cytokine storm in COVID-19. Theranostics. 2021; 11(1):316-329.
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The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2. Gene. 2021 Feb 05; 768:145325.
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Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways. Front Immunol. 2020; 11:606456.
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Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn's Disease and Regulated By Microbial and Inflammatory Signaling. Gastroenterology. 2021 02; 160(3):925-928.e4.