Methyl-CpG-Binding Protein 2
"Methyl-CpG-Binding Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-binding protein that interacts with methylated CPG ISLANDS. It plays a role in repressing GENETIC TRANSCRIPTION and is frequently mutated in RETT SYNDROME.
| Descriptor ID |
D051783
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| MeSH Number(s) |
D12.776.260.536 D12.776.660.235.550 D12.776.664.235.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Methyl-CpG-Binding Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Methyl-CpG-Binding Protein 2".
This graph shows the total number of publications written about "Methyl-CpG-Binding Protein 2" by people in this website by year, and whether "Methyl-CpG-Binding Protein 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 5 | 1 | 6 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Methyl-CpG-Binding Protein 2" by people in Profiles.
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Activation of the Medial Prefrontal Cortex Reverses Cognitive and Respiratory Symptoms in a Mouse Model of Rett Syndrome. eNeuro. 2017 Nov-Dec; 4(6).
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Single nucleotide polymorphism of Methyl-CpG-binding protein 2 gene associates with juvenile idiopathic arthritis. Clin Rheumatol. 2018 Feb; 37(2):375-381.
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Association Study of MECP2 Gene Single Nucleotide Polymorphisms in Juvenile-Onset Systemic Lupus Erythematosus Patients from Iran. Fetal Pediatr Pathol. 2017 Dec; 36(6):423-431.
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Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects. Elife. 2017 03 28; 6.
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A sibship with duplication of Xq28 inherited from the mother; genomic characterization and clinical outcomes. BMC Med Genet. 2017 03 17; 18(1):30.
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Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome. Sci Rep. 2017 01 31; 7:41701.
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Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E514-E523.
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Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome. Elife. 2016 06 21; 5.
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Rett syndrome: revised diagnostic criteria and nomenclature. Ann Neurol. 2010 Dec; 68(6):944-50.