"Prothrombin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
| Descriptor ID |
D011516
|
| MeSH Number(s) |
D08.622.709 D12.776.124.125.800 D23.119.945
|
| Concept/Terms |
Prothrombin- Prothrombin
- Factor II
- Blood Coagulation Factor II
- Differentiation Reversal Factor
- Factor, Differentiation Reversal
- Coagulation Factor II
- Factor II, Coagulation
- II, Coagulation Factor
|
Below are MeSH descriptors whose meaning is more general than "Prothrombin".
Below are MeSH descriptors whose meaning is more specific than "Prothrombin".
This graph shows the total number of publications written about "Prothrombin" by people in this website by year, and whether "Prothrombin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 5 | 6 |
| 2018 | 5 | 9 | 14 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 3 | 3 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Prothrombin" by people in Profiles.
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SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19. Biosci Rep. 2021 08 27; 41(8).
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COVID-19 and Antiphospholipid Antibodies: Time for a Reality Check? Semin Thromb Hemost. 2022 Feb; 48(1):72-92.
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Severe systemic thrombosis in a young COVID-19 patient with a rare homozygous prothrombin G20210A mutation. Infez Med. 2021 Jun 01; 29(2):259-262.
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COVID-19 diagnosis by routine blood tests using machine learning. Sci Rep. 2021 05 24; 11(1):10738.
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Validation of an admission coagulation panel for risk stratification of COVID-19 patients. PLoS One. 2021; 16(3):e0248230.
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Peptide Correlation Analysis (PeCorA) Reveals Differential Proteoform Regulation. J Proteome Res. 2021 04 02; 20(4):1972-1980.
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Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome. Front Immunol. 2020; 11:584241.
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Evaluation of the prothrombin fragment 1.2 in patients with coronavirus disease 2019 (COVID-19). Am J Hematol. 2020 12; 95(12):1479-1485.
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A prediction model of outcome of SARS-CoV-2 pneumonia based on laboratory findings. Sci Rep. 2020 08 20; 10(1):14042.
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Vitamin K deficiency and covid-19. Scand J Clin Lab Invest. 2020 11; 80(7):525-527.