"Histones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
| Descriptor ID |
D006657
|
| MeSH Number(s) |
D12.776.157.687.485 D12.776.660.720.485 D12.776.664.469
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Histones".
Below are MeSH descriptors whose meaning is more specific than "Histones".
This graph shows the total number of publications written about "Histones" by people in this website by year, and whether "Histones" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 2 | 3 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 5 | 6 |
| 2016 | 2 | 2 | 4 |
| 2017 | 31 | 27 | 58 |
| 2018 | 24 | 31 | 55 |
| 2019 | 6 | 7 | 13 |
| 2020 | 1 | 3 | 4 |
| 2021 | 0 | 3 | 3 |
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Below are the most recent publications written about "Histones" by people in Profiles.
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Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide. JCI Insight. 2021 09 08; 6(17).
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Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. Haematologica. 2021 09 01; 106(9):2493-2498.
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PCA-based unsupervised feature extraction for gene expression analysis of COVID-19 patients. Sci Rep. 2021 08 30; 11(1):17351.
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Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease. Int J Mol Sci. 2021 Aug 17; 22(16).
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Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients. Sci Rep. 2021 08 03; 11(1):15701.
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Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism. Theranostics. 2021; 11(16):7970-7983.
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Extracellular Vesicles and Citrullinated Histone H3 in Coronavirus Disease 2019 Patients. Thromb Haemost. 2022 Jan; 122(1):113-122.
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Histone deficiency and accelerated replication stress in T cell aging. J Clin Invest. 2021 06 01; 131(11).
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Genetic and epigenetic control of ACE2 expression and its possible role in COVID-19. Cell Biochem Funct. 2021 Aug; 39(6):713-726.
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Epigenetic alterations and genetic variations of angiotensin-converting enzyme 2 (ACE2) as a functional receptor for SARS-CoV-2: potential clinical implications. Eur J Clin Microbiol Infect Dis. 2021 Aug; 40(8):1587-1598.