Apoptosis Inducing Factor
"Apoptosis Inducing Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
Descriptor ID |
D051033
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MeSH Number(s) |
D08.811.682.608.047 D12.644.360.075.311 D12.776.157.687.063 D12.776.331.161 D12.776.476.075.311 D12.776.660.720.063
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Concept/Terms |
Apoptosis Inducing Factor- Apoptosis Inducing Factor
- Apoptosis-Inducing Factor
- Mitochondrial Apoptosis-Inducing Factor
- Apoptosis-Inducing Factor, Mitochondrial
- Mitochondrial Apoptosis Inducing Factor
- AIF Apoptosis Regulatory Protein
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Below are MeSH descriptors whose meaning is more general than "Apoptosis Inducing Factor".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis Inducing Factor".
This graph shows the total number of publications written about "Apoptosis Inducing Factor" by people in this website by year, and whether "Apoptosis Inducing Factor" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apoptosis Inducing Factor" by people in Profiles.
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a-Hederin Induces Apoptosis of Esophageal Squamous Cell Carcinoma via an Oxidative and Mitochondrial-Dependent Pathway. Dig Dis Sci. 2019 12; 64(12):3528-3538.
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Porcine epidemic diarrhea virus S1 protein is the critical inducer of apoptosis. Virol J. 2018 11 07; 15(1):170.
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p53- and ROS-mediated AIF pathway involved in TGEV-induced apoptosis. J Vet Med Sci. 2018 Nov 23; 80(11):1775-1781.
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Porcine epidemic diarrhea virus induces caspase-independent apoptosis through activation of mitochondrial apoptosis-inducing factor. Virology. 2014 Jul; 460-461:180-93.
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Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable. J Virol. 2012 Jan; 86(1):81-93.
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Proteomic analysis of up-regulated proteins in human promonocyte cells expressing severe acute respiratory syndrome coronavirus 3C-like protease. Proteomics. 2007 May; 7(9):1446-60.