Pore Forming Cytotoxic Proteins
"Pore Forming Cytotoxic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
| Descriptor ID |
D052899
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| MeSH Number(s) |
D12.776.543.695
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pore Forming Cytotoxic Proteins".
Below are MeSH descriptors whose meaning is more specific than "Pore Forming Cytotoxic Proteins".
This graph shows the total number of publications written about "Pore Forming Cytotoxic Proteins" by people in this website by year, and whether "Pore Forming Cytotoxic Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2017 | 1 | 1 | 2 |
| 2018 | 3 | 1 | 4 |
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Below are the most recent publications written about "Pore Forming Cytotoxic Proteins" by people in Profiles.
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Compelling Evidence for the Activity of Antiviral Peptides against SARS-CoV-2. Viruses. 2021 05 14; 13(5).
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Antimicrobial peptide DP7 with potential activity against SARS coronavirus infections. Signal Transduct Target Ther. 2021 04 01; 6(1):140.
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Deep Learning for Novel Antimicrobial Peptide Design. Biomolecules. 2021 03 22; 11(3).
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Delving Into the Origin of Destructive Inflammation in COVID-19: A Betrayal of Natural Host Defense Peptides? Front Immunol. 2020; 11:610024.
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Antimicrobial and Amyloidogenic Activity of Peptides. Can Antimicrobial Peptides Be Used against SARS-CoV-2? Int J Mol Sci. 2020 Dec 15; 21(24).
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In Silico Discovery of Antimicrobial Peptides as an Alternative to Control SARS-CoV-2. Molecules. 2020 Nov 25; 25(23).
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Binding of LcrV protein from Yersinia pestis to human T-cells induces apoptosis, which is completely blocked by specific antibodies. Int J Biol Macromol. 2019 Feb 01; 122:1062-1070.
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Understanding the Virulence of Staphylococcus pseudintermedius: A Major Role of Pore-Forming Toxins. Front Cell Infect Microbiol. 2018; 8:221.
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Potent Macromolecule-Sized Poration of Lipid Bilayers by the Macrolittins, A Synthetically Evolved Family of Pore-Forming Peptides. J Am Chem Soc. 2018 05 23; 140(20):6441-6447.
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Environmental pH modulates inerolysin activity via post-binding blockade. Sci Rep. 2018 01 24; 8(1):1542.