"Dystrophin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
| Descriptor ID |
D016189
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| MeSH Number(s) |
D12.776.210.500.250 D12.776.220.250 D12.776.543.250
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dystrophin".
Below are MeSH descriptors whose meaning is more specific than "Dystrophin".
This graph shows the total number of publications written about "Dystrophin" by people in this website by year, and whether "Dystrophin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Dystrophin" by people in Profiles.
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Gene editing for Duchenne muscular dystrophy. Nat Med. 2018 10; 24(10):1491.
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Gene-Editing Technology Accelerates Cardiovascular Research: Clinical Applications Being Explored. Circulation. 2018 02 27; 137(9):973-974.
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Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. Eur J Hum Genet. 2017 12; 25(12):1388-1396.
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Delivery of large transgene cassettes by foamy virus vector. Sci Rep. 2017 08 14; 7(1):8085.
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Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo. Biochem Soc Trans. 2007 Aug; 35(Pt 4):826-8.
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Effective amplification of 20-kb DNA by reverse transcription PCR. Anal Biochem. 1997 Oct 01; 252(1):62-70.