"Checkpoint Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.
| Descriptor ID |
D000071877
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.143
|
| Concept/Terms |
Checkpoint Kinase 1- Checkpoint Kinase 1
- Chk1 Kinase
- Chk1 Protein Kinase
- Protein Kinase, Chk1
- Checkpoint-1 Kinase
|
Below are MeSH descriptors whose meaning is more general than "Checkpoint Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "Checkpoint Kinase 1".
This graph shows the total number of publications written about "Checkpoint Kinase 1" by people in this website by year, and whether "Checkpoint Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 2 | 1 | 3 |
| 2018 | 0 | 4 | 4 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Checkpoint Kinase 1" by people in Profiles.
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Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells. Cancer Res. 2019 Oct 01; 79(19):4855-4868.
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Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway. Virol J. 2018 11 06; 15(1):169.
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APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Res. 2018 03 16; 46(5):2479-2494.
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Radiation-induced G2/M arrest rarely occurred in glioblastoma stem-like cells. Int J Radiat Biol. 2018 04; 94(4):394-402.
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A turning point in the fight against ovarian cancer? Lancet Oncol. 2018 02; 19(2):154-156.
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Checkpoint inhibitors and aspergillosis in AML: the double hit hypothesis. Lancet Oncol. 2017 12; 18(12):1571-1573.
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Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression. Sci Rep. 2017 08 14; 7(1):8078.
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ELABELA and an ELABELA Fragment Protect against AKI. J Am Soc Nephrol. 2017 Sep; 28(9):2694-2707.
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NSC746364, a G-quadruplex-stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of the ATR/Chk1-dependent pathway. J Pharmacol Sci. 2014; 124(1):7-17.
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Differential response of human acute myeloid leukemia cells to gemtuzumab ozogamicin in vitro: role of Chk1 and Chk2 phosphorylation and caspase 3. Blood. 2003 Jun 01; 101(11):4589-97.