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eIF-2 Kinase

"eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.

Descriptor ID	D019892
MeSH Number(s)	D08.811.913.696.620.682.700.300 D12.644.360.275 D12.776.476.275
Concept/Terms	eIF-2 Kinase eIF-2 Kinase Kinase, eIF-2 eIF 2 Kinase DAI Protein Kinase Kinase, DAI Protein Protein Kinase, DAI Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase Double Stranded RNA Dependent eIF 2 alpha Protein Kinase Double Stranded RNA-Dependent Kinase (dsl) dsRNA-Activated Inhibitor Inhibitor, dsRNA-Activated dsRNA Activated Inhibitor DSRNA-Dep Protein Kinase DSRNA Dep Protein Kinase Kinase, DSRNA-Dep Protein Protein Kinase, DSRNA-Dep eIF-2alpha Kinase Kinase, eIF-2alpha eIF 2alpha Kinase eRF, eIF-2 Recycling Factor eRF, eIF 2 Recycling Factor Eukaryotic Initiation Factor 2alpha Kinase Heme Controlled Repressor Controlled Repressor, Heme Repressor, Heme Controlled Heme-Controlled Inhibitor Heme Controlled Inhibitor Inhibitor, Heme-Controlled Heme-Regulated eIF-2alpha Kinase Heme Regulated eIF 2alpha Kinase Kinase, Heme-Regulated eIF-2alpha eIF-2alpha Kinase, Heme-Regulated Hemin Controlled Repressor Controlled Repressor, Hemin Repressor, Hemin Controlled p68 Kinase Kinase, p68 Self-Phosphorylating Protein Kinase Kinase, Self-Phosphorylating Protein Protein Kinase, Self-Phosphorylating Self Phosphorylating Protein Kinase TIK Kinase Kinase, TIK P68 Protein Kinase Kinase, P68 Protein Protein Kinase, P68 RNA-Dependent Protein Kinase Kinase, RNA-Dependent Protein Protein Kinase, RNA-Dependent RNA Dependent Protein Kinase p65 Kinase Kinase, p65 Protein Kinase PKR Kinase PKR, Protein PKR, Protein Kinase Protein Kinase, RNA Activated Heme-Controlled Translational Repressor Heme Controlled Translational Repressor Repressor, Heme-Controlled Translational Translational Repressor, Heme-Controlled Hemin-Controlled Translational Repressor Hemin Controlled Translational Repressor Repressor, Hemin-Controlled Translational Translational Repressor, Hemin-Controlled

Below are MeSH descriptors whose meaning is more general than "eIF-2 Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
eIF-2 Kinase [D08.811.913.696.620.682.700.300]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
eIF-2 Kinase [D12.644.360.275]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
eIF-2 Kinase [D12.776.476.275]

Below are MeSH descriptors whose meaning is related to "eIF-2 Kinase".

Below are MeSH descriptors whose meaning is more specific than "eIF-2 Kinase".

Publications

Timeline | Most Recent

This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether "eIF-2 Kinase" was a major or minor topic of these publications.

Bar chart showing 27 publications over 8 distinct years, with a maximum of 9 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2009	1	0	1
2016	1	1	2
2017	4	5	9
2018	5	3	8
2019	1	2	3
2020	0	1	1
2021	1	1	2

Below are the most recent publications written about "eIF-2 Kinase" by people in Profiles.

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Sci Adv. 2021 06; 7(25).

View in: PubMed
Induction of the Proinflammatory Chemokine Interleukin-8 Is Regulated by Integrated Stress Response and AP-1 Family Proteins Activated during Coronavirus Infection. Int J Mol Sci. 2021 May 26; 22(11).

View in: PubMed
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proc Natl Acad Sci U S A. 2021 04 20; 118(16).

View in: PubMed
The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta. Virus Res. 2021 04 15; 296:198350.

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Endoplasmic Reticulum Stress Markers in SARS-COV-2 Infection and Pneumonia: Case-Control Study. In Vivo. 2020 Jun; 34(3 Suppl):1645-1650.

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Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19. Life Sci. 2020 Aug 15; 255:117842.

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Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells. Cancer Sci. 2019 Oct; 110(10):3275-3287.

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ADAR1: "Editor-in-Chief" of Cytoplasmic Innate Immunity. Front Immunol. 2019; 10:1763.

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Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase. Virology. 2019 03; 529:226-233.

View in: PubMed
Sevoflurane relieves hepatic ischemia-reperfusion injury by inhibiting the expression of Grp78. Biosci Rep. 2018 10 31; 38(5).

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eIF-2 Kinase