"rho-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
| Descriptor ID |
D054460
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.814 D12.644.360.590 D12.776.476.595
|
| Concept/Terms |
rho-Associated Kinases- rho-Associated Kinases
- rho Associated Kinases
- rho-Associated Kinase
- rho Associated Kinase
- ROCK Protein Kinases
- Protein Kinases, ROCK
- rho-Associated Coiled-Coil Kinase
- Coiled-Coil Kinase, rho-Associated
- rho Associated Coiled Coil Kinase
- rho-Kinase
- rho Kinase
- ROK Kinase
rho-Associated Kinase 1- rho-Associated Kinase 1
- rho Associated Kinase 1
- ROCK-I Protein Kinase
- ROCK I Protein Kinase
- p160ROCK
- rho-Associated Kinase beta
- rho Associated Kinase beta
- rho-Associated Protein Kinase beta
- rho Associated Protein Kinase beta
- rho-Associated Coiled-Coil Containing Protein Kinase 1
- rho Associated Coiled Coil Containing Protein Kinase 1
rho-Associated Kinase 2- rho-Associated Kinase 2
- rho Associated Kinase 2
- rho-Associated Kinase alpha
- rho Associated Kinase alpha
- rho-Associated Coiled-Coil Containing Protein Kinase 2
- rho Associated Coiled Coil Containing Protein Kinase 2
- ROCK-II Protein Kinase
- ROCK II Protein Kinase
- p160 rhoA-Binding Kinase ROKalpha
- p160 rhoA Binding Kinase ROKalpha
- rho-Associated Protein Kinase alpha
- rho Associated Protein Kinase alpha
|
Below are MeSH descriptors whose meaning is more general than "rho-Associated Kinases".
Below are MeSH descriptors whose meaning is more specific than "rho-Associated Kinases".
This graph shows the total number of publications written about "rho-Associated Kinases" by people in this website by year, and whether "rho-Associated Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 2 | 4 |
| 2018 | 2 | 4 | 6 |
| 2019 | 1 | 1 | 2 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "rho-Associated Kinases" by people in Profiles.
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COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction. JCI Insight. 2021 09 08; 6(17).
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Rho kinase inhibitors for SARS-CoV-2 induced acute respiratory distress syndrome: Support from Bartter's and Gitelman's syndrome patients. Pharmacol Res. 2020 08; 158:104903.
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Plausibility of therapeutic effects of Rho kinase inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19). Pharmacol Res. 2020 06; 156:104808.
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Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs. Transl Res. 2019 12; 214:121-143.
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RhoA/rho-kinase, nitric oxide and inflammatory response in LIMA during OPCABG with isoflurane preconditioning. J Cardiothorac Surg. 2019 Jan 25; 14(1):22.
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miR-142-5p Improves Neural Differentiation and Proliferation of Adipose-Derived Stem Cells. Cell Physiol Biochem. 2018; 50(6):2097-2107.
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Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis. Int J Mol Med. 2019 Jan; 43(1):404-412.
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Oxidative stress and the altered reaction to it in Fabry disease: A possible target for cardiovascular-renal remodeling? PLoS One. 2018; 13(9):e0204618.
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Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L35-L44.
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Role of statins and mevalonate pathway on impaired HDAC2 activity induced by oxidative stress in human airway epithelial cells. Eur J Pharmacol. 2018 Aug 05; 832:114-119.