"p21-Activated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
| Descriptor ID |
D054462
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.596 D12.644.360.552 D12.776.476.548
|
| Concept/Terms |
p21-Activated Kinases- p21-Activated Kinases
- Kinases, p21-Activated
- p21 Activated Kinases
- PAK Kinases
- Kinases, PAK
p21-Activated Kinase 2- p21-Activated Kinase 2
- p21 Activated Kinase 2
- p65(PAK)
- p65PAK Protein
- PAK-2 Kinase
- PAK 2 Kinase
- PAK2 Kinase
- PAK65
- gamma-PAK
- gamma PAK
p21-Activated Kinase 1- p21-Activated Kinase 1
- p21 Activated Kinase 1
- Serine-Threonine-Protein Kinase PAK 1
- Serine Threonine Protein Kinase PAK 1
- alpha p21-Activated Kinase
- alpha p21 Activated Kinase
- alpha-PAK
- PAK1 Kinase
- PAK-1 Kinase
- PAK 1 Kinase
p21-Activated Kinase 3- p21-Activated Kinase 3
- p21 Activated Kinase 3
- Oligophrenin-3
- Oligophrenin 3
- Serine-Threonine-Protein Kinase PAK 3
- Serine Threonine Protein Kinase PAK 3
- PAK3 Kinase
- beta p21-Activated Kinase
- beta p21 Activated Kinase
- p21-Activated Kinase, beta
- beta-PAK
|
Below are MeSH descriptors whose meaning is more general than "p21-Activated Kinases".
Below are MeSH descriptors whose meaning is more specific than "p21-Activated Kinases".
This graph shows the total number of publications written about "p21-Activated Kinases" by people in this website by year, and whether "p21-Activated Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 5 | 1 | 6 |
| 2018 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "p21-Activated Kinases" by people in Profiles.
-
Porcine Hemagglutinating Encephalomyelitis Virus Activation of the Integrin a5ß1-FAK-Cofilin Pathway Causes Cytoskeletal Rearrangement To Promote Its Invasion of N2a Cells. J Virol. 2019 03 01; 93(5).
-
Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages. Immunobiology. 2018 11; 223(11):634-647.
-
Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis. Sci Signal. 2018 02 27; 11(519).
-
Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression. J Mol Cell Biol. 2017 10 01; 9(5):384-394.
-
miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients. Br J Cancer. 2017 Sep 26; 117(7):1036-1047.
-
Prognostic and Predictive Value of p21-activated Kinase 6 Associated Support Vector Machine Classifier in Gastric Cancer Treated by 5-fluorouracil/Oxaliplatin Chemotherapy. EBioMedicine. 2017 Aug; 22:78-88.
-
PAK5 mediates cell: cell adhesion integrity via interaction with E-cadherin in bladder cancer cells. Biochem J. 2017 Mar 24; 474(8):1333-1346.
-
p21-activated kinase 4 regulates HIF-1a translation in cancer cells. Biochem Biophys Res Commun. 2017 04 29; 486(2):270-276.
-
Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma. Blood. 2017 04 20; 129(16):2233-2245.