Insulin Receptor Substrate Proteins
"Insulin Receptor Substrate Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
| Descriptor ID |
D055504
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| MeSH Number(s) |
D12.644.360.024.301 D12.776.157.057.045 D12.776.476.024.382
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Insulin Receptor Substrate Proteins".
Below are MeSH descriptors whose meaning is more specific than "Insulin Receptor Substrate Proteins".
This graph shows the total number of publications written about "Insulin Receptor Substrate Proteins" by people in this website by year, and whether "Insulin Receptor Substrate Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 3 | 2 | 5 |
| 2018 | 2 | 1 | 3 |
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Below are the most recent publications written about "Insulin Receptor Substrate Proteins" by people in Profiles.
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Hepatic IRS1 and ß-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients. J Gastroenterol. 2018 Dec; 53(12):1261-1275.
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Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. J Clin Invest. 2018 03 01; 128(3):1010-1025.
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New mechanistic insights on the metabolic-disruptor role of chlorpyrifos in apoE mice: a focus on insulin- and leptin-signalling pathways. Arch Toxicol. 2018 05; 92(5):1717-1728.
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MicroRNA-191, acting via the IRS-1/Akt signaling pathway, is involved in the hepatic insulin resistance induced by cigarette smoke extract. Environ Sci Pollut Res Int. 2018 Aug; 25(23):22400-22407.
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A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes. Int J Mol Sci. 2017 Sep 21; 18(10).
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The phosphodiesterase 5 inhibitor tadalafil regulates lipidic homeostasis in human skeletal muscle cell metabolism. Endocrine. 2018 03; 59(3):602-613.
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Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly. Chronobiol Int. 2017; 34(8):1083-1093.
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Genome-Wide Methylation Analysis Identifies Specific Epigenetic Marks In Severely Obese Children. Sci Rep. 2017 04 07; 7:46311.
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12b-hydroxy-des-D-garcigerin A enhances glucose metabolism in insulin-resistant HepG2 cells via the IRS-1/PI3-K/Akt cell signaling pathway. J Asian Nat Prod Res. 2016 Nov; 18(11):1091-100.
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Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1415-22.