Suppressor of Cytokine Signaling Proteins
"Suppressor of Cytokine Signaling Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.
| Descriptor ID |
D050826
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| MeSH Number(s) |
D12.644.360.024.374 D12.776.157.057.249 D12.776.476.024.437
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling Proteins".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling Proteins".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling Proteins" by people in this website by year, and whether "Suppressor of Cytokine Signaling Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Suppressor of Cytokine Signaling Proteins" by people in Profiles.
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Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2. Drug Des Devel Ther. 2018; 12:2887-2896.
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SOCS6 Functions as a Tumor Suppressor by Inducing Apoptosis and Inhibiting Angiogenesis in Human Prostate Cancer. Curr Cancer Drug Targets. 2018; 18(9):894-904.
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Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action. Sci Rep. 2017 05 11; 7(1):1729.
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Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling. Elife. 2017 02 14; 6.
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Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer. Structure. 2016 08 02; 24(8):1248-1256.
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SOCS3 expression correlates with severity of inflammation in mouse hepatitis virus strain 3-induced acute liver failure and HBV-ACLF. J Huazhong Univ Sci Technolog Med Sci. 2014 Jun; 34(3):348-353.
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The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma. BMC Cancer. 2014 Mar 04; 14:149.
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Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production. Cytokine. 2011 Aug; 55(2):294-300.
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Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection. J Hepatol. 2009 Apr; 50(4):705-11.