Intrinsically Disordered Proteins
"Intrinsically Disordered Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.
| Descriptor ID |
D064267
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| MeSH Number(s) |
D12.776.481
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Intrinsically Disordered Proteins".
Below are MeSH descriptors whose meaning is more specific than "Intrinsically Disordered Proteins".
This graph shows the total number of publications written about "Intrinsically Disordered Proteins" by people in this website by year, and whether "Intrinsically Disordered Proteins" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 2 | 0 | 2 |
| 2017 | 15 | 2 | 17 |
| 2018 | 11 | 5 | 16 |
| 2019 | 5 | 0 | 5 |
| 2020 | 2 | 1 | 3 |
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Below are the most recent publications written about "Intrinsically Disordered Proteins" by people in Profiles.
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The method utilized to purify the SARS-CoV-2 N protein can affect its molecular properties. Int J Biol Macromol. 2021 Oct 01; 188:391-403.
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Tackling Covid-19 using disordered-to-order transition of residues in the spike protein upon angiotensin-converting enzyme 2 binding. Proteins. 2021 09; 89(9):1158-1166.
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Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications. Sci Signal. 2021 01 12; 14(665).
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A Novel Strategy for the Development of Vaccines for SARS-CoV-2 (COVID-19) and Other Viruses Using AI and Viral Shell Disorder. J Proteome Res. 2020 11 06; 19(11):4355-4363.
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Shell Disorder Analysis Suggests That Pangolins Offered a Window for a Silent Spread of an Attenuated SARS-CoV-2 Precursor among Humans. J Proteome Res. 2020 11 06; 19(11):4543-4552.
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Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses. Cell Mol Life Sci. 2021 Feb; 78(4):1655-1688.
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Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases. Prog Mol Biol Transl Sci. 2019; 166:145-223.
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Protein intrinsic disorder and structure-function continuum. Prog Mol Biol Transl Sci. 2019; 166:1-17.
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Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation. Trends Biochem Sci. 2019 08; 44(8):716-728.
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Torches, Candles, Lamps, Lanterns, Flashlights, Spotlights, Night Vision Goggles… You Need Them All to See in Darkness. Proteomics. 2019 03; 19(6):e1900085.