"Prions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
| Descriptor ID |
D011328
|
| MeSH Number(s) |
D12.776.785
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| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Prions".
Below are MeSH descriptors whose meaning is more specific than "Prions".
This graph shows the total number of publications written about "Prions" by people in this website by year, and whether "Prions" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Prions" by people in Profiles.
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SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. Biochem Biophys Res Commun. 2021 05 21; 554:94-98.
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The PentaFOLD 3.0 Algorithm for the Selection of Stable Elements of Secondary Structure to be Included in Vaccine Peptides. Protein Pept Lett. 2021; 28(5):573-588.
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The 20th Anniversary Meeting of the Rocky Mountain Virology Association. Viruses. 2020 12 29; 13(1).
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Recent advances on the molecular pathogenesis of prion diseases. Brain Pathol. 2019 03; 29(2):245-247.
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A two-way road: novel roles for fungal extracellular vesicles. Mol Microbiol. 2018 10; 110(1):11-15.
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A Practical Primer on Prion Pathology. J Neuropathol Exp Neurol. 2018 05 01; 77(5):346-352.
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New blood tests make strides in detecting prion disease. Science. 2016 Dec 23; 354(6319):1512.
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The inhibition of functional expression of calcium channels by prion protein demonstrates competition with a2d for GPI-anchoring pathways. Biochem J. 2014 Mar 01; 458(2):365-74.
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Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases. Metallomics. 2011 Nov; 3(11):1163-80.
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The unfolded state of the murine prion protein and properties of single-point mutants related to human prion diseases. J Mol Biol. 2010 Aug 06; 401(1):7-12.