Protein Aggregation, Pathological
"Protein Aggregation, Pathological" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION, POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Descriptor ID |
D066263
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| MeSH Number(s) |
C23.550.770 G02.111.675
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Aggregation, Pathological".
Below are MeSH descriptors whose meaning is more specific than "Protein Aggregation, Pathological".
This graph shows the total number of publications written about "Protein Aggregation, Pathological" by people in this website by year, and whether "Protein Aggregation, Pathological" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 5 | 6 | 11 |
| 2018 | 2 | 5 | 7 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Aggregation, Pathological" by people in Profiles.
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SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFN?-Induced Antiviral Gene Expression in Human Lung Epithelial Cells. Front Immunol. 2021; 12:679482.
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The Intersection of Parkinson's Disease, Viral Infections, and COVID-19. Mol Neurobiol. 2021 Sep; 58(9):4477-4486.
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SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. Biochem Biophys Res Commun. 2021 05 21; 554:94-98.
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Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID-19 on Parkinson's Disease. Mov Disord. 2020 09; 35(9):1495-1496.
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Analyzing aggregation propensities of clinically relevant PTEN mutants: a new culprit in pathogenesis of cancer and other PTENopathies. J Biomol Struct Dyn. 2020 May; 38(8):2253-2266.
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A novel p.(Glu111Val) missense mutation in GUCA1A associated with cone-rod dystrophy leads to impaired calcium sensing and perturbed second messenger homeostasis in photoreceptors. Hum Mol Genet. 2018 12 15; 27(24):4204-4217.
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miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease. Cell Physiol Biochem. 2018; 51(6):2732-2745.
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Pathophysiological mechanisms linking F-box only protein 7 (FBXO7) and Parkinson's disease (PD). Mutat Res Rev Mutat Res. 2018 Oct - Dec; 778:72-78.
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Effect of altered solution conditions on tau conformational dynamics: Plausible implication on order propensity and aggregation. Biochim Biophys Acta Proteins Proteom. 2018 May - Jun; 1866(5-6):668-679.
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Propagation of an Aß Dodecamer Strain Involves a Three-Step Mechanism and a Key Intermediate. Biophys J. 2018 02 06; 114(3):539-549.