"DNA Cleavage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A reaction that severs one of the covalent sugar-phosphate linkages between NUCLEOTIDES that compose the sugar phosphate backbone of DNA. It is catalyzed enzymatically, chemically or by radiation. Cleavage may be exonucleolytic - removing the end nucleotide, or endonucleolytic - splitting the strand in two.
| Descriptor ID |
D053837
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| MeSH Number(s) |
G02.111.210 G05.193
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA Cleavage".
Below are MeSH descriptors whose meaning is more specific than "DNA Cleavage".
This graph shows the total number of publications written about "DNA Cleavage" by people in this website by year, and whether "DNA Cleavage" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 2 | 3 |
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Below are the most recent publications written about "DNA Cleavage" by people in Profiles.
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Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a. J Chem Inf Model. 2020 12 28; 60(12):6427-6437.
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Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses. Protein Eng Des Sel. 2017 07 01; 30(7):503-522.
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Synthesis, X-ray crystal structure, DNA/BSA binding, DNA cleavage and cytotoxicity studies of phenanthroline based copper(II)/zinc(II) complexes. Biometals. 2017 08; 30(4):575-587.
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Development of an assay to assess genotoxicity by particulate matter extract. Mol Med Rep. 2017 Apr; 15(4):1738-1746.