"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 3 | 4 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 3 | 5 |
| 2010 | 2 | 4 | 6 |
| 2011 | 0 | 4 | 4 |
| 2012 | 3 | 1 | 4 |
| 2013 | 1 | 2 | 3 |
| 2014 | 1 | 7 | 8 |
| 2015 | 0 | 6 | 6 |
| 2016 | 1 | 10 | 11 |
| 2017 | 19 | 105 | 124 |
| 2018 | 20 | 110 | 130 |
| 2019 | 3 | 54 | 57 |
| 2020 | 0 | 17 | 17 |
| 2021 | 4 | 16 | 20 |
To return to the timeline, click here.
Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Resveratrol supplementation reduces ACE2 expression in human adipose tissue. Adipocyte. 2021 12; 10(1):408-411.
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Qing-Fei-Pai-Du decoction and wogonoside exert anti-inflammatory action through down-regulating USP14 to promote the degradation of activating transcription factor 2. FASEB J. 2021 09; 35(9):e21870.
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Acute Cardiac Injury in Coronavirus Disease 2019 and Other Viral Infections-A Systematic Review and Meta-Analysis. Crit Care Med. 2021 09 01; 49(9):1558-1566.
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Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease. Sci Rep. 2021 08 19; 11(1):16843.
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SELP Asp603Asn and severe thrombosis in COVID-19 males. J Hematol Oncol. 2021 08 16; 14(1):123.
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Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children. Nat Commun. 2021 08 11; 12(1):4854.
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Low level of plasminogen increases risk for mortality in COVID-19 patients. Cell Death Dis. 2021 08 05; 12(8):773.
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Circulating miRNAs: Potential diagnostic role for coronavirus disease 2019 (COVID-19). Infect Genet Evol. 2021 10; 94:105020.
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SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway. Eur J Pharmacol. 2021 Oct 05; 908:174374.
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SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney. PLoS Pathog. 2021 07; 17(7):e1009705.