"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
|
| MeSH Number(s) |
G02.111.905 G05.308.850 G07.690.773.998
|
| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 4 | 5 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 4 | 4 |
| 2009 | 1 | 7 | 8 |
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 3 | 3 |
| 2012 | 2 | 8 | 10 |
| 2013 | 0 | 5 | 5 |
| 2014 | 1 | 11 | 12 |
| 2015 | 0 | 7 | 7 |
| 2016 | 1 | 9 | 10 |
| 2017 | 25 | 171 | 196 |
| 2018 | 26 | 152 | 178 |
| 2019 | 14 | 54 | 68 |
| 2020 | 2 | 23 | 25 |
| 2021 | 4 | 33 | 37 |
To return to the timeline, click here.
Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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Increased expression of hypoxia-induced factor 1a mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients. Ann Med. 2021 12; 53(1):197-207.
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Increased Angiotensin-Converting Enzyme 2 and Loss of Alveolar Type II Cells in COVID-19-related Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2021 11 01; 204(9):1024-1034.
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S100A8 may govern hyper-inflammation in severe COVID-19. FASEB J. 2021 09; 35(9):e21798.
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A virus-free cellular model recapitulates several features of severe COVID-19. Sci Rep. 2021 09 01; 11(1):17473.
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Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients. PLoS One. 2021; 16(8):e0256226.
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Functional Characterization of Organoids Derived From Irreversibly Damaged Liver of Patients With NASH. Hepatology. 2021 10; 74(4):1825-1844.
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Do Elevated Levels of Inflammatory Biomarkers Predict the Risk of Occurrence of Ischemic Stroke in SARS-CoV2 ?: An Observational Study. J Stroke Cerebrovasc Dis. 2021 Nov; 30(11):106063.
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Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies. Cell Stress Chaperones. 2021 09; 26(5):859-868.
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Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples. EBioMedicine. 2021 Aug; 70:103525.
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Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19? Adv Biol Regul. 2021 08; 81:100820.