Urokinase-Type Plasminogen Activator
"Urokinase-Type Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
| Descriptor ID |
D014568
|
| MeSH Number(s) |
D08.811.277.656.300.760.910 D08.811.277.656.959.350.910 D12.776.124.125.662.884
|
| Concept/Terms |
Urokinase-Type Plasminogen Activator- Urokinase-Type Plasminogen Activator
- Urokinase Type Plasminogen Activator
- Plasminogen Activator, Urokinase-Type
- U-Plasminogen Activator
- U Plasminogen Activator
- U-PA
- Urinary Plasminogen Activator
- Urokinase
|
Below are MeSH descriptors whose meaning is more general than "Urokinase-Type Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Urokinase-Type Plasminogen Activator".
This graph shows the total number of publications written about "Urokinase-Type Plasminogen Activator" by people in this website by year, and whether "Urokinase-Type Plasminogen Activator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 2 | 4 | 6 |
| 2018 | 3 | 2 | 5 |
| 2019 | 2 | 1 | 3 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Urokinase-Type Plasminogen Activator" by people in Profiles.
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Normal Response to Fibrinolytic Challenge in COVID-19 Patients: Viscoelastic Evaluation Using Urokinase-Modified Thromboelastography. J Am Coll Surg. 2021 05; 232(5):803-805.
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SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung. Elife. 2021 03 08; 10.
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Rheolytic thrombectomy with local thrombolysis in a patient with COVID-19 pneumonia and acute pulmonary embolism. Pol Arch Intern Med. 2021 03 30; 131(3):292-294.
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Fibrinolysis is a reasonable alternative for STEMI care during the COVID-19 pandemic. J Int Med Res. 2020 Oct; 48(10):300060520966151.
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Structural analysis of experimental drugs binding to the SARS-CoV-2 target TMPRSS2. J Mol Graph Model. 2020 11; 100:107710.
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COVID-19 and pneumonia: a role for the uPA/uPAR system. Drug Discov Today. 2020 08; 25(8):1528-1534.
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Coronavirus Disease 2019: The Role of the Fibrinolytic System from Transmission to Organ Injury and Sequelae. Semin Thromb Hemost. 2020 10; 46(7):841-844.
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Prognostic role of the urokinase plasminogen activator (uPA) system in patients with nonmuscle invasive bladder cancer. Urol Oncol. 2019 10; 37(10):774-783.
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A comprehensive report of long-term outcomes after catheter-directed thrombolysis for occluded infrainguinal bypass grafts. J Vasc Surg. 2019 10; 70(4):1205-1216.
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Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator-dependent manner. J Trauma Acute Care Surg. 2019 01; 86(1):101-107.