"Furin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
| Descriptor ID |
D045683
|
| MeSH Number(s) |
D08.811.277.656.300.760.353 D08.811.277.656.837.249 D08.811.277.656.959.350.353
|
| Concept/Terms |
Furin- Furin
- Dibasic Processing Enzyme
- Processing Enzyme, Dibasic
- Furin Protein
- SPC1 Proteinase
- Paired Basic Amino Acid Cleaving Enzyme
|
Below are MeSH descriptors whose meaning is more general than "Furin".
Below are MeSH descriptors whose meaning is more specific than "Furin".
This graph shows the total number of publications written about "Furin" by people in this website by year, and whether "Furin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 2 | 0 | 2 |
| 2016 | 0 | 2 | 2 |
| 2017 | 3 | 0 | 3 |
| 2018 | 1 | 1 | 2 |
| 2020 | 10 | 14 | 24 |
| 2021 | 10 | 8 | 18 |
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Below are the most recent publications written about "Furin" by people in Profiles.
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SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity. mBio. 2021 08 31; 12(4):e0141521.
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OFF-State-Specific Inhibition of the Proprotein Convertase Furin. ACS Chem Biol. 2021 09 17; 16(9):1692-1700.
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Natural and Recombinant SARS-CoV-2 Isolates Rapidly Evolve In Vitro to Higher Infectivity through More Efficient Binding to Heparan Sulfate and Reduced S1/S2 Cleavage. J Virol. 2021 10 13; 95(21):e0135721.
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How SARS-CoV-2 might affect potassium balance via impairing epithelial sodium channels? Mol Biol Rep. 2021 Sep; 48(9):6655-6661.
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Why All the Fury over Furin? J Med Chem. 2022 02 24; 65(4):2747-2784.
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The mutation that helps Delta spread like wildfire. Nature. 2021 08; 596(7873):472-473.
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D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage. mBio. 2021 08 31; 12(4):e0058721.
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Structural modelling of SARS-CoV-2 alpha variant (B.1.1.7) suggests enhanced furin binding and infectivity. Virus Res. 2021 10 02; 303:198522.
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COVID-19. Stem Cell Res. 2021 08; 55:102468.
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Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals. Arch Virol. 2021 Sep; 166(9):2541-2549.