Mannose-Binding Protein-Associated Serine Proteases
"Mannose-Binding Protein-Associated Serine Proteases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.
| Descriptor ID |
D050606
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| MeSH Number(s) |
D08.811.277.656.300.760.501 D08.811.277.656.959.350.501 D12.776.124.486.274.045.387.875
|
| Concept/Terms |
Mannose-Binding Protein-Associated Serine Proteases- Mannose-Binding Protein-Associated Serine Proteases
- Mannose-Binding Protein-Associated Serine Protease
- Mannose Binding Protein Associated Serine Protease
- MBP-Associated Serine Protease
- MBP Associated Serine Protease
- Serine Protease, MBP-Associated
- MASPs
- Mannan-Binding Lectin Serine Proteases
- Mannan Binding Lectin Serine Proteases
- MBL-Associated Serine Proteases
- MBL Associated Serine Proteases
- Serine Proteases, MBL-Associated
- MASP Proteases
- Proteases, MASP
MASP-Related Protein- MASP-Related Protein
- MASP Related Protein
- Protein, MASP-Related
- MBP-Associated Serine Protease-Related Protein
- MBP Associated Serine Protease Related Protein
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Below are MeSH descriptors whose meaning is more general than "Mannose-Binding Protein-Associated Serine Proteases".
Below are MeSH descriptors whose meaning is more specific than "Mannose-Binding Protein-Associated Serine Proteases".
This graph shows the total number of publications written about "Mannose-Binding Protein-Associated Serine Proteases" by people in this website by year, and whether "Mannose-Binding Protein-Associated Serine Proteases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 0 | 2 | 2 |
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Below are the most recent publications written about "Mannose-Binding Protein-Associated Serine Proteases" by people in Profiles.
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Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics. Pharmacol Rev. 2021 04; 73(2):792-827.
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Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections. Viruses. 2021 02 17; 13(2).
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Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab. Immunobiology. 2020 11; 225(6):152001.
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Anti-complement C5 therapy with eculizumab in three cases of critical COVID-19. Clin Immunol. 2020 10; 219:108555.
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[Study on interaction between SARS-CoV N and MAP19]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Sep; 25(9):777-9.
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Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection. BMC Infect Dis. 2009 May 01; 9:51.