"Trypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
| Descriptor ID |
D014357
|
| MeSH Number(s) |
D08.811.277.656.300.760.895 D08.811.277.656.959.350.895
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Trypsin".
Below are MeSH descriptors whose meaning is more specific than "Trypsin".
This graph shows the total number of publications written about "Trypsin" by people in this website by year, and whether "Trypsin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 3 | 3 | 6 |
| 2018 | 1 | 4 | 5 |
| 2019 | 0 | 2 | 2 |
| 2020 | 1 | 4 | 5 |
| 2021 | 0 | 3 | 3 |
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Below are the most recent publications written about "Trypsin" by people in Profiles.
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SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19. Biosci Rep. 2021 08 27; 41(8).
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SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells. Microbiol Spectr. 2021 09 03; 9(1):e0077421.
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Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases. Int J Mol Sci. 2021 May 29; 22(11).
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SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab. 2021 08 03; 33(8):1577-1591.e7.
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Does Trypsin Oral Spray (Viruprotect®/ColdZyme®) Protect against COVID-19 and Common Colds or Induce Mutation? Caveats in Medical Device Regulations in the European Union. Int J Environ Res Public Health. 2021 05 11; 18(10).
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Quantifying the effect of trypsin and elastase on in vitro SARS-CoV infections. Virus Res. 2021 07 02; 299:198423.
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Structural leitmotif and functional variations of the structural catalytic core in (chymo)trypsin-like serine/cysteine fold proteinases. Int J Biol Macromol. 2021 May 15; 179:601-609.
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Inactivation of SARS-CoV-2 and HCoV-229E in vitro by ColdZyme® a medical device mouth spray against the common cold. J Med Virol. 2021 03; 93(3):1792-1795.
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Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection. Infect Genet Evol. 2020 10; 84:104498.
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Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease. J Biol Chem. 2020 09 04; 295(36):12686-12696.