"NLR Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.
| Descriptor ID |
D000070576
|
| MeSH Number(s) |
D12.644.360.539
|
| Concept/Terms |
NLR Proteins- NLR Proteins
- Proteins, NLR
- NLR Protein
- Protein, NLR
- NOD-like Receptors
- NOD like Receptors
- Receptors, NOD-like
- Nucleotide-binding Domain Leucine-rich Repeat Proteins
- Nucleotide binding Domain Leucine rich Repeat Proteins
|
Below are MeSH descriptors whose meaning is more general than "NLR Proteins".
Below are MeSH descriptors whose meaning is more specific than "NLR Proteins".
This graph shows the total number of publications written about "NLR Proteins" by people in this website by year, and whether "NLR Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 2 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "NLR Proteins" by people in Profiles.
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Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections. Cell Rep. 2021 08 24; 36(8):109614.
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Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic Suggestions. Int J Mol Sci. 2021 Feb 20; 22(4).
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The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins. Int J Mol Sci. 2021 Jan 22; 22(3).
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The NLRP1 Inflammasome Pathway Is Silenced in Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2019 08; 139(8):1788-1797.e6.
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Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing. J Invest Dermatol. 2018 12; 138(12):2644-2652.
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Inflammasomes and type 2 diabetes: An updated systematic review. Immunol Lett. 2017 12; 192:97-103.
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African and Asian Zika virus strains differentially induce early antiviral responses in primary human astrocytes. Infect Genet Evol. 2017 04; 49:134-137.
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Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery. ACS Nano. 2017 01 24; 11(1):54-68.