Activating Transcription Factor 6
"Activating Transcription Factor 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.
| Descriptor ID |
D051702
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| MeSH Number(s) |
D12.644.360.011 D12.776.260.108.061.968 D12.776.476.011 D12.776.930.127.061.968
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Activating Transcription Factor 6".
Below are MeSH descriptors whose meaning is more specific than "Activating Transcription Factor 6".
This graph shows the total number of publications written about "Activating Transcription Factor 6" by people in this website by year, and whether "Activating Transcription Factor 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Activating Transcription Factor 6" by people in Profiles.
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Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs. Mol Cell Proteomics. 2021; 20:100120.
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Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection. PLoS Pathog. 2021 06; 17(6):e1009644.
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The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta. Virus Res. 2021 04 15; 296:198350.
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Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19. Life Sci. 2020 Aug 15; 255:117842.
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The PERK Arm of the Unfolded Protein Response Negatively Regulates Transmissible Gastroenteritis Virus Replication by Suppressing Protein Translation and Promoting Type I Interferon Production. J Virol. 2018 08 01; 92(15).
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Avian metapneumovirus subgroup C induces autophagy through the ATF6 UPR pathway. Autophagy. 2017 Oct 03; 13(10):1709-1721.
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[Protective effect of notoginsenoside R1 on neuron injury induced by OGD/R through ATF6/Akt signaling pathway]. Zhongguo Zhong Yao Za Zhi. 2017 Mar; 42(6):1167-1174.
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Coronavirus-induced ER stress response and its involvement in regulation of coronavirus-host interactions. Virus Res. 2014 Dec 19; 194:110-23.
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The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6. Virology. 2009 May 10; 387(2):402-13.