"Janus Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains.
| Descriptor ID |
D053612
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| MeSH Number(s) |
D08.811.913.696.620.682.725.124 D12.776.476.393
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Janus Kinases".
Below are MeSH descriptors whose meaning is more specific than "Janus Kinases".
This graph shows the total number of publications written about "Janus Kinases" by people in this website by year, and whether "Janus Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2017 | 8 | 9 | 17 |
| 2018 | 5 | 7 | 12 |
| 2019 | 2 | 3 | 5 |
| 2020 | 2 | 6 | 8 |
| 2021 | 5 | 3 | 8 |
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Below are the most recent publications written about "Janus Kinases" by people in Profiles.
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A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19. Eur Respir J. 2021 10; 58(4).
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SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021 09 09; 95(19):e0086221.
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The janus-kinase inhibitor ruxolitinib in SARS-CoV-2 induced acute respiratory distress syndrome (ARDS). Leukemia. 2021 10; 35(10):2917-2923.
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The Many Faces of JAKs and STATs Within the COVID-19 Storm. Front Immunol. 2021; 12:690477.
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SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation. EMBO J. 2021 08 02; 40(15):e107826.
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SARS-CoV-2 infection in a pediatrics STAT1 GOF patient under Ruxolitinib therapy-a matter of balance? J Clin Immunol. 2021 10; 41(7):1502-1506.
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Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms. Int J Mol Sci. 2021 Jun 09; 22(12).
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JAK inhibitors: Ten years after. Eur J Immunol. 2021 07; 51(7):1615-1627.
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The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all? Cytokine. 2021 08; 144:155593.
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SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights. Front Immunol. 2021; 12:635018.