Autophagy-Related Protein-1 Homolog
"Autophagy-Related Protein-1 Homolog" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.
| Descriptor ID |
D000071189
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| MeSH Number(s) |
D08.811.913.696.620.682.700.108 D12.644.360.081 D12.776.094.438 D12.776.476.078
|
| Concept/Terms |
Autophagy-Related Protein-1 Homolog- Autophagy-Related Protein-1 Homolog
- Autophagy Related Protein 1 Homolog
- Serine-Threonine Protein Kinase ULK1
- Serine Threonine Protein Kinase ULK1
- Unc-51 Like Autophagy Activating Kinase 1
- Unc 51 Like Autophagy Activating Kinase 1
- ULK1 Protein
- Unc-51-Like Kinase 1
- Unc 51 Like Kinase 1
|
Below are MeSH descriptors whose meaning is more general than "Autophagy-Related Protein-1 Homolog".
Below are MeSH descriptors whose meaning is more specific than "Autophagy-Related Protein-1 Homolog".
This graph shows the total number of publications written about "Autophagy-Related Protein-1 Homolog" by people in this website by year, and whether "Autophagy-Related Protein-1 Homolog" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Autophagy-Related Protein-1 Homolog" by people in Profiles.
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Porcine Hemagglutinating Encephalomyelitis Virus Triggers Neural Autophagy Independently of ULK1. J Virol. 2021 09 09; 95(19):e0085121.
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The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy. Biochem Biophys Res Commun. 2021 02 12; 540:75-82.
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Suppression of SARS-CoV-2 infection in ex-vivo human lung tissues by targeting class III phosphoinositide 3-kinase. J Med Virol. 2021 04; 93(4):2076-2083.
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Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders. J Virol. 2018 08 15; 92(16).
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RIG-I and IL-6 are negative-feedback regulators of STING induced by double-stranded DNA. PLoS One. 2017; 12(8):e0182961.
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SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways. Oncol Rep. 2017 Jun; 37(6):3449-3458.
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miR-142-5p Disrupts Neuronal Morphogenesis Underlying Porcine Hemagglutinating Encephalomyelitis Virus Infection by Targeting Ulk1. Front Cell Infect Microbiol. 2017; 7:155.
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Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):E3462-E3471.
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The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J Cell Biol. 2010 Oct 04; 191(1):155-68.